Why is olfactory neuroepithelium?
Currently, most cellular therapeutic effects for nervous diseases cannot be proven in a multicenter, randomized, double-blind placebo-control clinical trials, except for a few kinds of cells such as olfactory ensheathing cells. These cells show significant improvements in functional recovery and qua...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Journal of Neurorestoratology |
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| Online Access: | https://www.sciopen.com/article/10.26599/JNR.2021.9040026 |
| _version_ | 1797710165474017280 |
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| author | Hongyun Huang |
| author_facet | Hongyun Huang |
| author_sort | Hongyun Huang |
| collection | DOAJ |
| description | Currently, most cellular therapeutic effects for nervous diseases cannot be proven in a multicenter, randomized, double-blind placebo-control clinical trials, except for a few kinds of cells such as olfactory ensheathing cells. These cells show significant improvements in functional recovery and quality of life for patients with chronic ischemic stroke. Also, olfactory neuron transplantation has promising neurorestorative effects on patients with vascular dementia. Human olfactory neuroepithelium can spontaneously and sustainably regenerate or produce new olfactory neurons and glial cell types for decades or a lifetime. The neurorestorative mechanisms of olfactory ensheathing cells are well known; however, little is known about the neurorestorative mechanisms of olfactory neurons. Therefore, I hypothesize that the neurorestorative mechanisms of olfactory neurons after transplantation: (1) can well migrate where they are needed and become local functional neurons, as they need to compensate or replace; (2) must be regulated by some special molecular factors to elongate their axons, modulate or direct synapses to correctly recognize and connect the target cells, and integrate functions. Based on olfactory neuroepithelium cells displaying the special characterization, neurorestorative mechanisms, clinical therapeutic achievements, and hypotheses of effective mechanisms, they (olfactory ensheathing cells and olfactory neurons) may be the most efficient instruments of neurorestoration. |
| first_indexed | 2024-03-12T06:48:17Z |
| format | Article |
| id | doaj.art-71946e5607224f299ac18927cfb669c1 |
| institution | Directory Open Access Journal |
| issn | 2324-2426 |
| language | English |
| last_indexed | 2024-03-12T06:48:17Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Neurorestoratology |
| spelling | doaj.art-71946e5607224f299ac18927cfb669c12023-09-03T00:27:29ZengElsevierJournal of Neurorestoratology2324-24262021-12-019421121810.26599/JNR.2021.9040026Why is olfactory neuroepithelium?Hongyun Huang0Beijing Hongtianji Neuroscience Academy, Beijing 100143, ChinaCurrently, most cellular therapeutic effects for nervous diseases cannot be proven in a multicenter, randomized, double-blind placebo-control clinical trials, except for a few kinds of cells such as olfactory ensheathing cells. These cells show significant improvements in functional recovery and quality of life for patients with chronic ischemic stroke. Also, olfactory neuron transplantation has promising neurorestorative effects on patients with vascular dementia. Human olfactory neuroepithelium can spontaneously and sustainably regenerate or produce new olfactory neurons and glial cell types for decades or a lifetime. The neurorestorative mechanisms of olfactory ensheathing cells are well known; however, little is known about the neurorestorative mechanisms of olfactory neurons. Therefore, I hypothesize that the neurorestorative mechanisms of olfactory neurons after transplantation: (1) can well migrate where they are needed and become local functional neurons, as they need to compensate or replace; (2) must be regulated by some special molecular factors to elongate their axons, modulate or direct synapses to correctly recognize and connect the target cells, and integrate functions. Based on olfactory neuroepithelium cells displaying the special characterization, neurorestorative mechanisms, clinical therapeutic achievements, and hypotheses of effective mechanisms, they (olfactory ensheathing cells and olfactory neurons) may be the most efficient instruments of neurorestoration.https://www.sciopen.com/article/10.26599/JNR.2021.9040026olfactory neuroepitheliumolfactory ensheathing cellsolfactory neuronsneurorestoration |
| spellingShingle | Hongyun Huang Why is olfactory neuroepithelium? Journal of Neurorestoratology olfactory neuroepithelium olfactory ensheathing cells olfactory neurons neurorestoration |
| title | Why is olfactory neuroepithelium? |
| title_full | Why is olfactory neuroepithelium? |
| title_fullStr | Why is olfactory neuroepithelium? |
| title_full_unstemmed | Why is olfactory neuroepithelium? |
| title_short | Why is olfactory neuroepithelium? |
| title_sort | why is olfactory neuroepithelium |
| topic | olfactory neuroepithelium olfactory ensheathing cells olfactory neurons neurorestoration |
| url | https://www.sciopen.com/article/10.26599/JNR.2021.9040026 |
| work_keys_str_mv | AT hongyunhuang whyisolfactoryneuroepithelium |