Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study
Background: Central obesity is a leading cause of insulin resistance, type 2 diabetes mellitus, dyslipidemia, and Cardiovascular Disease (CVD). Central obesity may act as an independent predictor for CVD. Aim and Objectives: To study the correlation of central obesity among obese patients with the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2023-04-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
| Subjects: | |
| Online Access: | https://www.jkimsu.com/jkimsu-vol12no2/JKIMSU,%20Vol.%2012,%20No.%202,%20April-June%202023%20Page%2081-93.pdf |
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| author | Mohd Danish Khan Mohammad Kaleem Ahmad Roshan Alam Saba Khan Geeta Jaiswal Arjumand Jahan Mohammad Mustufa Khan |
| author_facet | Mohd Danish Khan Mohammad Kaleem Ahmad Roshan Alam Saba Khan Geeta Jaiswal Arjumand Jahan Mohammad Mustufa Khan |
| author_sort | Mohd Danish Khan |
| collection | DOAJ |
| description | Background: Central obesity is a leading cause of insulin resistance, type 2 diabetes mellitus, dyslipidemia, and Cardiovascular Disease (CVD). Central obesity may act as an independent predictor for CVD. Aim and Objectives: To
study the correlation of central obesity among obese patients with the risk factors for CVD. Material and Methods: In this case-control study, 50 non-obese and 50 obese subjects aged between 30-70 years were enrolled. Biochemical
parameters: Fasting Blood Sugar (FBS), Glycated Hemoglobin (HbA1c), Total Cholesterol (TC), Triglyceride (TG), High-Density Lipoprotein-Cholesterol (HDL-C) and Low-Density Lipoprotein-Cholesterol (LDL-C) were estimated along with Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Body Mass Index (BMI) and Waist Circumference (WC). Value of p less than 0.05 was considered statistically significant. Results: Mean of FBS, HbA1c, TC, TG, LDL-C, SBP, DBP, BMI, and WC were significantly raised in obese compared to non-obese (p<0.01).
However, the mean of HDL-C was significantly low in obese compared to non-obese (p<0.01). A significant positive correlation was found between age and WC (r=0.426, p<0.01), TC and TG (r=0.628, p<0.01), TC and LDL-C (r=0.934,
p<0.01), TG and LDL-C (r=0.647, p<0.01) among obese. However, a significant negative correlation was found between TC and HDL-C (r=-0.453, p<0.01), TG and HDL-C (r=-0.323, p<0.05), and HDL-C and LDL-C (r=-0.510, p<0.01) among obese. Linear regression analysis model was found significant. Conclusion: Result showed that WC is an independent predictive marker for CVD. Further study is needed in larger sample to strengthen the hypothesis. |
| first_indexed | 2024-03-11T20:45:24Z |
| format | Article |
| id | doaj.art-71950c1d9234494b9b891a05415d62d9 |
| institution | Directory Open Access Journal |
| issn | 2231-4261 |
| language | English |
| last_indexed | 2025-03-20T05:42:17Z |
| publishDate | 2023-04-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj.art-71950c1d9234494b9b891a05415d62d92024-10-03T05:10:37ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612023-04-011228193Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control studyMohd Danish Khan0 Mohammad Kaleem Ahmad1Roshan Alam 2Saba Khan3Geeta Jaiswal4Arjumand Jahan5Mohammad Mustufa Khan6Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow-226026 (Uttar Pradesh) IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003 (Uttar Pradesh) India, Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow-226026 (Uttar Pradesh) IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow-226026 (Uttar Pradesh) IndiaDepartment of Biochemistry, United Institute of Medical Sciences, Prayagraj-211012 (Uttar Pradesh) IndiaDepartment of Radio-diagnosis, Moti Lal Nehru Medical College, Prayagraj-211001 (Uttar Pradesh) IndiaDepartment of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow-226026 (Uttar Pradesh) IndiaBackground: Central obesity is a leading cause of insulin resistance, type 2 diabetes mellitus, dyslipidemia, and Cardiovascular Disease (CVD). Central obesity may act as an independent predictor for CVD. Aim and Objectives: To study the correlation of central obesity among obese patients with the risk factors for CVD. Material and Methods: In this case-control study, 50 non-obese and 50 obese subjects aged between 30-70 years were enrolled. Biochemical parameters: Fasting Blood Sugar (FBS), Glycated Hemoglobin (HbA1c), Total Cholesterol (TC), Triglyceride (TG), High-Density Lipoprotein-Cholesterol (HDL-C) and Low-Density Lipoprotein-Cholesterol (LDL-C) were estimated along with Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Body Mass Index (BMI) and Waist Circumference (WC). Value of p less than 0.05 was considered statistically significant. Results: Mean of FBS, HbA1c, TC, TG, LDL-C, SBP, DBP, BMI, and WC were significantly raised in obese compared to non-obese (p<0.01). However, the mean of HDL-C was significantly low in obese compared to non-obese (p<0.01). A significant positive correlation was found between age and WC (r=0.426, p<0.01), TC and TG (r=0.628, p<0.01), TC and LDL-C (r=0.934, p<0.01), TG and LDL-C (r=0.647, p<0.01) among obese. However, a significant negative correlation was found between TC and HDL-C (r=-0.453, p<0.01), TG and HDL-C (r=-0.323, p<0.05), and HDL-C and LDL-C (r=-0.510, p<0.01) among obese. Linear regression analysis model was found significant. Conclusion: Result showed that WC is an independent predictive marker for CVD. Further study is needed in larger sample to strengthen the hypothesis.https://www.jkimsu.com/jkimsu-vol12no2/JKIMSU,%20Vol.%2012,%20No.%202,%20April-June%202023%20Page%2081-93.pdfbody mass indexcardiovascular diseasediastolic blood pressurefasting blood sugarsystolic blood pressurewaist circumference |
| spellingShingle | Mohd Danish Khan Mohammad Kaleem Ahmad Roshan Alam Saba Khan Geeta Jaiswal Arjumand Jahan Mohammad Mustufa Khan Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study Journal of Krishna Institute of Medical Sciences University body mass index cardiovascular disease diastolic blood pressure fasting blood sugar systolic blood pressure waist circumference |
| title | Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study |
| title_full | Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study |
| title_fullStr | Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study |
| title_full_unstemmed | Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study |
| title_short | Association of central obesity with risk factors for cardiovascular disease in North Indian population: A case - control study |
| title_sort | association of central obesity with risk factors for cardiovascular disease in north indian population a case control study |
| topic | body mass index cardiovascular disease diastolic blood pressure fasting blood sugar systolic blood pressure waist circumference |
| url | https://www.jkimsu.com/jkimsu-vol12no2/JKIMSU,%20Vol.%2012,%20No.%202,%20April-June%202023%20Page%2081-93.pdf |
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