COX-2 Expression in Hepatocytes Improves Mitochondrial Function after Hepatic Ischemia-Reperfusion Injury

COX-2 Expression in Hepatocytes Improves Mitochondrial Function after Hepatic Ischemia-Reperfusion Injury

Cyclooxygenase 2 (COX-2) is a key enzyme in prostanoid biosynthesis. The constitutive hepatocyte expression of COX-2 has a protective role in hepatic ischemia-reperfusion (I/R) injury (IRI), decreasing necrosis, reducing reactive oxygen species (ROS) levels, and increasing autophagy and antioxidant...

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Bibliographic Details
Main Authors: Marina Fuertes-Agudo, María Luque-Tévar, Carme Cucarella, Rocío Brea, Lisardo Boscá, Rubén Quintana-Cabrera, Paloma Martín-Sanz, Marta Casado
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
COX-2
prostaglandins
liver
ischemia-reperfusion
high-resolution respirometry
mitochondrial dynamics
Online Access:https://www.mdpi.com/2076-3921/11/9/1724

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