Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography
Summary: Vasoconstriction is a crucial physiological process that serves as the body’s primary blood pressure regulation mechanism and a key marker of numerous harmful health conditions. The ability to detect vasoconstriction in real time would be crucial for detecting blood pressure, identifying sy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223002614 |
| _version_ | 1797894667519393792 |
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| author | Nathan Zavanelli Sung Hoon Lee Matthew Guess Woon-Hong Yeo |
| author_facet | Nathan Zavanelli Sung Hoon Lee Matthew Guess Woon-Hong Yeo |
| author_sort | Nathan Zavanelli |
| collection | DOAJ |
| description | Summary: Vasoconstriction is a crucial physiological process that serves as the body’s primary blood pressure regulation mechanism and a key marker of numerous harmful health conditions. The ability to detect vasoconstriction in real time would be crucial for detecting blood pressure, identifying sympathetic arousals, characterizing patient wellbeing, detecting sickle cell anemia attacks early, and identifying complications caused by hypertension medications. However, vasoconstriction manifests weakly in traditional photoplethysmogram (PPG) measurement locations, like the finger, toe, and ear. Here, we report a wireless, fully integrated, soft sternal patch to capture PPG signals from the sternum, an anatomical region that exhibits a robust vasoconstrictive response. With healthy controls, the device is highly capable of detecting vasoconstriction induced endogenously and exogenously. Furthermore, in overnight trials with patients with sleep apnea, the device shows a high agreement (r2 = 0.74) in vasoconstriction detection with a commercial system, demonstrating its potential use in portable, continuous, long-term vasoconstriction monitoring. |
| first_indexed | 2024-04-10T07:14:06Z |
| format | Article |
| id | doaj.art-71981aadeb1e4bd785a17bc2dd40bd72 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T07:14:06Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-71981aadeb1e4bd785a17bc2dd40bd722023-02-26T04:27:44ZengElsevieriScience2589-00422023-03-01263106184Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmographyNathan Zavanelli0Sung Hoon Lee1Matthew Guess2Woon-Hong Yeo3George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30024, USA; IEN Center for Human-Centric Interfaces and Engineering at the Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USAIEN Center for Human-Centric Interfaces and Engineering at the Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USAGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30024, USA; IEN Center for Human-Centric Interfaces and Engineering at the Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USAGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30024, USA; IEN Center for Human-Centric Interfaces and Engineering at the Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University School of Medicine, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Biosciences, Neural Engineering Center, Institute for Materials, Institute for Robotics and Intelligent Machines, Georgia Institute of Technology, Atlanta, GA 30332, USA; Corresponding authorSummary: Vasoconstriction is a crucial physiological process that serves as the body’s primary blood pressure regulation mechanism and a key marker of numerous harmful health conditions. The ability to detect vasoconstriction in real time would be crucial for detecting blood pressure, identifying sympathetic arousals, characterizing patient wellbeing, detecting sickle cell anemia attacks early, and identifying complications caused by hypertension medications. However, vasoconstriction manifests weakly in traditional photoplethysmogram (PPG) measurement locations, like the finger, toe, and ear. Here, we report a wireless, fully integrated, soft sternal patch to capture PPG signals from the sternum, an anatomical region that exhibits a robust vasoconstrictive response. With healthy controls, the device is highly capable of detecting vasoconstriction induced endogenously and exogenously. Furthermore, in overnight trials with patients with sleep apnea, the device shows a high agreement (r2 = 0.74) in vasoconstriction detection with a commercial system, demonstrating its potential use in portable, continuous, long-term vasoconstriction monitoring.http://www.sciencedirect.com/science/article/pii/S2589004223002614Health sciencesBiological sciencesBiotechnologyBioelectronicsEngineering |
| spellingShingle | Nathan Zavanelli Sung Hoon Lee Matthew Guess Woon-Hong Yeo Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography iScience Health sciences Biological sciences Biotechnology Bioelectronics Engineering |
| title | Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| title_full | Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| title_fullStr | Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| title_full_unstemmed | Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| title_short | Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| title_sort | soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography |
| topic | Health sciences Biological sciences Biotechnology Bioelectronics Engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223002614 |
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