The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn’s disease risk allele ATG16L1 T300A results in abnormal Paneth cells due to decreased...

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Bibliographic Details
Main Authors: Sydney Lavoie, Kara L Conway, Kara G Lassen, Humberto B Jijon, Hui Pan, Eunyoung Chun, Monia Michaud, Jessica K Lang, Carey Ann Gallini Comeau, Jonathan M Dreyfuss, Jonathan N Glickman, Hera Vlamakis, Ashwin Ananthakrishnan, Aleksander Kostic, Wendy S Garrett, Ramnik J Xavier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Bacteroides
Bacteroides ovatus
Crohn's Disease
gut
T cell
ATG16L1T300A
Online Access:https://elifesciences.org/articles/39982

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