Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus
Objective To describe interactions among cytokines and to identify subgroups of systemic lupus erythematosus (SLE) patients based on cytokine levels using principal component analysis and cluster analysis. Methods Levels of 12 cytokines were measured using sensitive multiplex bead assays and associa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520926882 |
| _version_ | 1830357996627034112 |
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| author | Joonhong Park Woori Jang Hye Sun Park Ki Hyun Park Seung-Ki Kwok Sung-Hwan Park Eun-Jee Oh |
| author_facet | Joonhong Park Woori Jang Hye Sun Park Ki Hyun Park Seung-Ki Kwok Sung-Hwan Park Eun-Jee Oh |
| author_sort | Joonhong Park |
| collection | DOAJ |
| description | Objective To describe interactions among cytokines and to identify subgroups of systemic lupus erythematosus (SLE) patients based on cytokine levels using principal component analysis and cluster analysis. Methods Levels of 12 cytokines were measured using sensitive multiplex bead assays and associations with SLE features including disease activity and renal involvement were assessed. Results In a group of 203 SLE patients, strong correlations were observed between interleukin (IL)6 and interferon (IFN)γ levels (r = 0.624), IL17 and IFNγ levels (r = 0.768), and macrophage inflammatory protein (MIP)1α and MIP1β levels (r = 0.675). Cluster analysis revealed two distinct patient groups characterized by high levels of IL8, MIP1α, and MIP1β (group 1) or of IL2, IL6, IL10, IL12, IFNγ, and tumor necrosis factor α (group 2). Active disease was more common in group 1 (49/88, 55.7%) than in group 2 (40/115, 34.8%). More patients in group 2 had renal involvement (42/115, 36.5%) than in group 1 (22/88, 25%). Conclusions Assessment of cytokine profiles can identify distinct SLE patient subgroups and aid in understanding clinical heterogeneity and immunological phenotypes. |
| first_indexed | 2024-12-20T02:33:20Z |
| format | Article |
| id | doaj.art-7198e363959147a8bc6207993bf33cef |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-20T02:33:20Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-7198e363959147a8bc6207993bf33cef2022-12-21T19:56:31ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520926882Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosusJoonhong ParkWoori JangHye Sun ParkKi Hyun ParkSeung-Ki KwokSung-Hwan ParkEun-Jee OhObjective To describe interactions among cytokines and to identify subgroups of systemic lupus erythematosus (SLE) patients based on cytokine levels using principal component analysis and cluster analysis. Methods Levels of 12 cytokines were measured using sensitive multiplex bead assays and associations with SLE features including disease activity and renal involvement were assessed. Results In a group of 203 SLE patients, strong correlations were observed between interleukin (IL)6 and interferon (IFN)γ levels (r = 0.624), IL17 and IFNγ levels (r = 0.768), and macrophage inflammatory protein (MIP)1α and MIP1β levels (r = 0.675). Cluster analysis revealed two distinct patient groups characterized by high levels of IL8, MIP1α, and MIP1β (group 1) or of IL2, IL6, IL10, IL12, IFNγ, and tumor necrosis factor α (group 2). Active disease was more common in group 1 (49/88, 55.7%) than in group 2 (40/115, 34.8%). More patients in group 2 had renal involvement (42/115, 36.5%) than in group 1 (22/88, 25%). Conclusions Assessment of cytokine profiles can identify distinct SLE patient subgroups and aid in understanding clinical heterogeneity and immunological phenotypes.https://doi.org/10.1177/0300060520926882 |
| spellingShingle | Joonhong Park Woori Jang Hye Sun Park Ki Hyun Park Seung-Ki Kwok Sung-Hwan Park Eun-Jee Oh Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus Journal of International Medical Research |
| title | Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| title_full | Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| title_fullStr | Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| title_full_unstemmed | Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| title_short | Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| title_sort | cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus |
| url | https://doi.org/10.1177/0300060520926882 |
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