Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/8/1700 |
| _version_ | 1797584106711678976 |
|---|---|
| author | Andrea Graziani Giuseppe Grande Michel Martin Giordana Ferraioli Elena Colonnello Massimo Iafrate Fabrizio Dal Moro Alberto Ferlin |
| author_facet | Andrea Graziani Giuseppe Grande Michel Martin Giordana Ferraioli Elena Colonnello Massimo Iafrate Fabrizio Dal Moro Alberto Ferlin |
| author_sort | Andrea Graziani |
| collection | DOAJ |
| description | Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of 8–8.2%. CP/CPPS is most frequent in men younger than 50 years, among whom it is the most common urologic diagnosis. In the last decades, many studies have been published on CP/CPPS and its association with male infertility. The pathophysiologic relation between CP/CPPS and male infertility involves several aspects, which are not well studied yet. A reduction in semen parameters has been demonstrated in patients with CP/CPPS, and several mechanisms have been proposed to represent putative pathophysiological links between CP/CPPS and infertility, including male accessory gland inflammation, metabolic syndrome, inflammatory bowel disease, HPV co-infection and autoimmunity. In light of this evidence, a multidisciplinary approach is advocated for patients with known CP/CPPS, and particular attention is needed for male patients of infertile couples in order to evaluate male accessory glands correctly. In addition, it is advisable that future studies dealing with the treatment of CP/CPPS take into consideration all the different pathophysiological aspects implicated. |
| first_indexed | 2024-03-10T23:47:34Z |
| format | Article |
| id | doaj.art-719a06dde71e46f4b37ead5049c27c28 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T23:47:34Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-719a06dde71e46f4b37ead5049c27c282023-11-19T01:54:20ZengMDPI AGLife2075-17292023-08-01138170010.3390/life13081700Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male InfertilityAndrea Graziani0Giuseppe Grande1Michel Martin2Giordana Ferraioli3Elena Colonnello4Massimo Iafrate5Fabrizio Dal Moro6Alberto Ferlin7Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35122 Padova, ItalyUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35122 Padova, ItalyUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35122 Padova, ItalyUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, ItalyUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, ItalyUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35122 Padova, ItalyChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of 8–8.2%. CP/CPPS is most frequent in men younger than 50 years, among whom it is the most common urologic diagnosis. In the last decades, many studies have been published on CP/CPPS and its association with male infertility. The pathophysiologic relation between CP/CPPS and male infertility involves several aspects, which are not well studied yet. A reduction in semen parameters has been demonstrated in patients with CP/CPPS, and several mechanisms have been proposed to represent putative pathophysiological links between CP/CPPS and infertility, including male accessory gland inflammation, metabolic syndrome, inflammatory bowel disease, HPV co-infection and autoimmunity. In light of this evidence, a multidisciplinary approach is advocated for patients with known CP/CPPS, and particular attention is needed for male patients of infertile couples in order to evaluate male accessory glands correctly. In addition, it is advisable that future studies dealing with the treatment of CP/CPPS take into consideration all the different pathophysiological aspects implicated.https://www.mdpi.com/2075-1729/13/8/1700chronic prostatitischronic pelvic pain syndromemale infertility |
| spellingShingle | Andrea Graziani Giuseppe Grande Michel Martin Giordana Ferraioli Elena Colonnello Massimo Iafrate Fabrizio Dal Moro Alberto Ferlin Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility Life chronic prostatitis chronic pelvic pain syndrome male infertility |
| title | Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility |
| title_full | Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility |
| title_fullStr | Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility |
| title_full_unstemmed | Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility |
| title_short | Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility |
| title_sort | chronic prostatitis chronic pain pelvic syndrome and male infertility |
| topic | chronic prostatitis chronic pelvic pain syndrome male infertility |
| url | https://www.mdpi.com/2075-1729/13/8/1700 |
| work_keys_str_mv | AT andreagraziani chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT giuseppegrande chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT michelmartin chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT giordanaferraioli chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT elenacolonnello chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT massimoiafrate chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT fabriziodalmoro chronicprostatitischronicpainpelvicsyndromeandmaleinfertility AT albertoferlin chronicprostatitischronicpainpelvicsyndromeandmaleinfertility |