The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition

The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition

Septic shock is defined as a subset of sepsis, which is associated with a considerably high mortality risk. The caspase-11 non-canonical inflammasome is sensed and activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis, it plays a critical role in septic shock. However, there are...

Full description

Bibliographic Details
Main Authors: Deqing Ruan, Jingyi Yang, Qianfei Luo, Yanhong Shi, Lili Ding, Zhengtao Wang, Rui Wang, Li Yang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
goitrin 1
septic shock 2
lipopolysaccharide 3
caspase-11 4
pyroptosis 5
Online Access:https://www.mdpi.com/1420-3049/28/7/2883

Internet

https://www.mdpi.com/1420-3049/28/7/2883

Similar Items