AMR mechanisms in L. interrogans serovars: a comprehensive study
Antimicrobial resistance (AMR) is one of the global health challenges of the 21st century. Data regarding AMR mechanisms in Leptospira interrogans, the causative agents of leptospirosis, have been relatively limited. Therefore, our study aimed to identify resistance genes and explore potential resis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1384427/full |
| _version_ | 1827287456120045568 |
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| author | Pavlo Petakh Pavlo Petakh Oleksandr Kamyshnyi |
| author_facet | Pavlo Petakh Pavlo Petakh Oleksandr Kamyshnyi |
| author_sort | Pavlo Petakh |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is one of the global health challenges of the 21st century. Data regarding AMR mechanisms in Leptospira interrogans, the causative agents of leptospirosis, have been relatively limited. Therefore, our study aimed to identify resistance genes and explore potential resistance mechanisms specific to particular serovars. We conducted a comprehensive analysis of 98 Leptospira strains, representing 10 common serovars, using whole-genome sequencing (WGS) FASTA files. Employing the PATRIC tool from the Bacterial and Viral Bioinformatics Resource Center (BV-BRC), we scrutinized the genomes for AMR genes. Our investigation revealed 32 genes associated with AMR, with 20 key genes consistently prevalent across most strains. Notably, we identified unique efflux pump systems in serovar Pomona, indicating distinctive resistance mechanisms in this serovar. In summary, our findings shed light on the genetic landscape of AMR in Leptospira, uncovering both common and serovar-specific resistance elements. The presence of unique efflux pump systems in serovar Pomona introduces a novel dimension to our understanding of resistance mechanisms. These insights underscore the importance of tailored intervention strategies and collaborative efforts between human and veterinary healthcare professionals, as well as environmental scientists, to address the complex dynamics of leptospirosis and its implications for antibiotic resistance. |
| first_indexed | 2024-04-24T10:59:46Z |
| format | Article |
| id | doaj.art-719b1d0ab95d421f96889510ad2e907a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-24T10:59:46Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-719b1d0ab95d421f96889510ad2e907a2024-04-12T02:32:38ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-04-011410.3389/fcimb.2024.13844271384427AMR mechanisms in L. interrogans serovars: a comprehensive studyPavlo Petakh0Pavlo Petakh1Oleksandr Kamyshnyi2Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, UkraineDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineAntimicrobial resistance (AMR) is one of the global health challenges of the 21st century. Data regarding AMR mechanisms in Leptospira interrogans, the causative agents of leptospirosis, have been relatively limited. Therefore, our study aimed to identify resistance genes and explore potential resistance mechanisms specific to particular serovars. We conducted a comprehensive analysis of 98 Leptospira strains, representing 10 common serovars, using whole-genome sequencing (WGS) FASTA files. Employing the PATRIC tool from the Bacterial and Viral Bioinformatics Resource Center (BV-BRC), we scrutinized the genomes for AMR genes. Our investigation revealed 32 genes associated with AMR, with 20 key genes consistently prevalent across most strains. Notably, we identified unique efflux pump systems in serovar Pomona, indicating distinctive resistance mechanisms in this serovar. In summary, our findings shed light on the genetic landscape of AMR in Leptospira, uncovering both common and serovar-specific resistance elements. The presence of unique efflux pump systems in serovar Pomona introduces a novel dimension to our understanding of resistance mechanisms. These insights underscore the importance of tailored intervention strategies and collaborative efforts between human and veterinary healthcare professionals, as well as environmental scientists, to address the complex dynamics of leptospirosis and its implications for antibiotic resistance.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1384427/fullLeptospira interrogansantibioticresistanceleptospiral serovarsleptospirosis |
| spellingShingle | Pavlo Petakh Pavlo Petakh Oleksandr Kamyshnyi AMR mechanisms in L. interrogans serovars: a comprehensive study Frontiers in Cellular and Infection Microbiology Leptospira interrogans antibiotic resistance leptospiral serovars leptospirosis |
| title | AMR mechanisms in L. interrogans serovars: a comprehensive study |
| title_full | AMR mechanisms in L. interrogans serovars: a comprehensive study |
| title_fullStr | AMR mechanisms in L. interrogans serovars: a comprehensive study |
| title_full_unstemmed | AMR mechanisms in L. interrogans serovars: a comprehensive study |
| title_short | AMR mechanisms in L. interrogans serovars: a comprehensive study |
| title_sort | amr mechanisms in l interrogans serovars a comprehensive study |
| topic | Leptospira interrogans antibiotic resistance leptospiral serovars leptospirosis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1384427/full |
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