Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities

Melanoma is characterized by high glucose uptake, partially mediated through elevated pyruvate dehydrogenase kinase (PDK), making PDK a potential treatment target in melanoma. We aimed to reduce glucose uptake in melanoma cell lines through PDK inhibitors dichloroacetate (DCA) and AZD7545 and throug...

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Bibliographic Details
Main Authors: Jiske F. Tiersma, Bernard Evers, Barbara M. Bakker, Mathilde Jalving, Steven de Jong
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
metabolism
dichloroacetate
metabolic reprogramming
Online Access:https://www.mdpi.com/1422-0067/23/7/3745

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