Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography
Abstract Morphological changes in capillaries are one of major clinical signs in diabetic retinopathy (DR). In this study, we quantified the dilated deep capillaries on optical coherence tomography angiography (OCTA) images. Central 3 × 3 mm en face images were obtained using a swept source OCTA dev...
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44848-3 |
| _version_ | 1797576979992543232 |
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| author | Noriko Terada Tomoaki Murakami Kenji Ishihara Keiichi Nishikawa Kentaro Kawai Akitaka Tsujikawa |
| author_facet | Noriko Terada Tomoaki Murakami Kenji Ishihara Keiichi Nishikawa Kentaro Kawai Akitaka Tsujikawa |
| author_sort | Noriko Terada |
| collection | DOAJ |
| description | Abstract Morphological changes in capillaries are one of major clinical signs in diabetic retinopathy (DR). In this study, we quantified the dilated deep capillaries on optical coherence tomography angiography (OCTA) images. Central 3 × 3 mm en face images were obtained using a swept source OCTA device in 105 eyes of 99 patients with DR. Capillaries with a greater diameter in the deep layers were defined as the dilated deep capillaries, using stepwise image processing. The relative areas of automatically selected capillaries with a great diameter were calculated as the index of the dilated deep capillaries. Most eyes with DR had string-like or dot-like dilated deep capillaries in the OCTA images, which appeared to be dilated capillary segments or microaneurysms histologically. They were distributed more densely in the parafovea than in the central sector, while there were no differences between individual quadrants. The index of the dilated deep capillaries was higher in eyes with DR than in nondiabetic eyes. The index in the central subfield was modestly associated with visual acuity, diabetic macular edema, and proliferative diabetic retinopathy. The quantitative dilated deep capillaries are designated as a biomarker of vision-threatening DR. |
| first_indexed | 2024-03-10T22:01:26Z |
| format | Article |
| id | doaj.art-719f7ebf284e429ea7345a720b90bdbf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T22:01:26Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-719f7ebf284e429ea7345a720b90bdbf2023-11-19T12:57:02ZengNature PortfolioScientific Reports2045-23222023-10-0113111110.1038/s41598-023-44848-3Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiographyNoriko Terada0Tomoaki Murakami1Kenji Ishihara2Keiichi Nishikawa3Kentaro Kawai4Akitaka Tsujikawa5Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineAbstract Morphological changes in capillaries are one of major clinical signs in diabetic retinopathy (DR). In this study, we quantified the dilated deep capillaries on optical coherence tomography angiography (OCTA) images. Central 3 × 3 mm en face images were obtained using a swept source OCTA device in 105 eyes of 99 patients with DR. Capillaries with a greater diameter in the deep layers were defined as the dilated deep capillaries, using stepwise image processing. The relative areas of automatically selected capillaries with a great diameter were calculated as the index of the dilated deep capillaries. Most eyes with DR had string-like or dot-like dilated deep capillaries in the OCTA images, which appeared to be dilated capillary segments or microaneurysms histologically. They were distributed more densely in the parafovea than in the central sector, while there were no differences between individual quadrants. The index of the dilated deep capillaries was higher in eyes with DR than in nondiabetic eyes. The index in the central subfield was modestly associated with visual acuity, diabetic macular edema, and proliferative diabetic retinopathy. The quantitative dilated deep capillaries are designated as a biomarker of vision-threatening DR.https://doi.org/10.1038/s41598-023-44848-3 |
| spellingShingle | Noriko Terada Tomoaki Murakami Kenji Ishihara Keiichi Nishikawa Kentaro Kawai Akitaka Tsujikawa Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography Scientific Reports |
| title | Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| title_full | Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| title_fullStr | Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| title_full_unstemmed | Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| title_short | Quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| title_sort | quantification of dilated deep capillaries in diabetic retinopathy on optical coherence tomography angiography |
| url | https://doi.org/10.1038/s41598-023-44848-3 |
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