Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial
The effect of probiotics in improving or maintaining oral health in orthodontic patients is understudied. The aim of this study is to evaluate the effect of probiotic administration in addition to tooth brushing on clinical gingival inflammation, plaque formation, subgingival microbiota composition,...
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MDPI AG
2022-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/2/112 |
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| author | Kevimy Agossa Marie Dubar Grégoire Lemaire Alessandra Blaizot Céline Catteau Emmanuël Bocquet Laurent Nawrocki Emile Boyer Vincent Meuric Florence Siepmann |
| author_facet | Kevimy Agossa Marie Dubar Grégoire Lemaire Alessandra Blaizot Céline Catteau Emmanuël Bocquet Laurent Nawrocki Emile Boyer Vincent Meuric Florence Siepmann |
| author_sort | Kevimy Agossa |
| collection | DOAJ |
| description | The effect of probiotics in improving or maintaining oral health in orthodontic patients is understudied. The aim of this study is to evaluate the effect of probiotic administration in addition to tooth brushing on clinical gingival inflammation, plaque formation, subgingival microbiota composition, and salivary biomarkers of inflammation in adolescents with fixed orthodontic appliances. The present study is a 6-month, double-blind, two-arm, placebo-controlled, single-center trial, in which 116 adolescent volunteers aged 12–16 years will be recruited from the patients of the orthodontics clinic of the University Hospital of Lille, France. Subjects who meet the eligibility criteria will be allocated to one of the following groups: (i) control: two placebo lozenges per day for 90 days together with regular oral hygiene, (ii) test: two probiotic lozenges per day for 90 days together with regular oral hygiene. Clinical assessment and biological sample collection will be performed at baseline, 3 and 6 months. In addition, compliance outcomes and adverse events will be monitored. |
| first_indexed | 2024-03-09T21:16:57Z |
| format | Article |
| id | doaj.art-719fe1f1cf224bd4af7b8dd968f4c781 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T21:16:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-719fe1f1cf224bd4af7b8dd968f4c7812023-11-23T21:30:34ZengMDPI AGPathogens2076-08172022-01-0111211210.3390/pathogens11020112Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control TrialKevimy Agossa0Marie Dubar1Grégoire Lemaire2Alessandra Blaizot3Céline Catteau4Emmanuël Bocquet5Laurent Nawrocki6Emile Boyer7Vincent Meuric8Florence Siepmann9Univ. Lille, Inserm, CHU Lille, U1008—Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, FranceDepartment of Periodontology, School of Dentistry, University of Lille, Place de Verdun, F-59000 Lille, FranceDepartment of Periodontology, School of Dentistry, University of Lille, Place de Verdun, F-59000 Lille, FranceDepartment of Dental Public Health, School of Dentistry, CHU Lille, Univ. Lille, F-59000 Lille, FranceDepartment of Dental Public Health, School of Dentistry, CHU Lille, Univ. Lille, F-59000 Lille, FranceDepartment of Orthodontics, School of Dentistry, CHU Lille, Univ. Lille, F-59037 Lille, FranceDepartment of Oral Surgery, School of Dentistry, CHU Lille, Univ. Lille, F-59037 Lille, FranceINSERM, INRAE, Université de Rennes 1, CHU de Rennes, Nutrition Metabolisms and Cancer, F-35000 Rennes, FranceINSERM, INRAE, Université de Rennes 1, CHU de Rennes, Nutrition Metabolisms and Cancer, F-35000 Rennes, FranceUniv. Lille, Inserm, CHU Lille, U1008—Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, FranceThe effect of probiotics in improving or maintaining oral health in orthodontic patients is understudied. The aim of this study is to evaluate the effect of probiotic administration in addition to tooth brushing on clinical gingival inflammation, plaque formation, subgingival microbiota composition, and salivary biomarkers of inflammation in adolescents with fixed orthodontic appliances. The present study is a 6-month, double-blind, two-arm, placebo-controlled, single-center trial, in which 116 adolescent volunteers aged 12–16 years will be recruited from the patients of the orthodontics clinic of the University Hospital of Lille, France. Subjects who meet the eligibility criteria will be allocated to one of the following groups: (i) control: two placebo lozenges per day for 90 days together with regular oral hygiene, (ii) test: two probiotic lozenges per day for 90 days together with regular oral hygiene. Clinical assessment and biological sample collection will be performed at baseline, 3 and 6 months. In addition, compliance outcomes and adverse events will be monitored.https://www.mdpi.com/2076-0817/11/2/112probioticsadolescentsorthodontic treatmentprevention |
| spellingShingle | Kevimy Agossa Marie Dubar Grégoire Lemaire Alessandra Blaizot Céline Catteau Emmanuël Bocquet Laurent Nawrocki Emile Boyer Vincent Meuric Florence Siepmann Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial Pathogens probiotics adolescents orthodontic treatment prevention |
| title | Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial |
| title_full | Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial |
| title_fullStr | Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial |
| title_full_unstemmed | Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial |
| title_short | Effect of <i>Lactobacillus reuteri</i> on Gingival Inflammation and Composition of the Oral Microbiota in Patients Undergoing Treatment with Fixed Orthodontic Appliances: Study Protocol of a Randomized Control Trial |
| title_sort | effect of i lactobacillus reuteri i on gingival inflammation and composition of the oral microbiota in patients undergoing treatment with fixed orthodontic appliances study protocol of a randomized control trial |
| topic | probiotics adolescents orthodontic treatment prevention |
| url | https://www.mdpi.com/2076-0817/11/2/112 |
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