A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib
Key Clinical Message Immunosuppression, malnutrition, and underlying infection can unmask obscure infections which can be challenging to identify. Early diagnosis and treatment of infections in immunosuppressed patients are essential due to high morbidity and mortality. Abstract The immunosuppressiv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.7362 |
| _version_ | 1797820442644316160 |
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| author | Benjamin M. Moy Abhishek Shenoy Leslie B. Aldrich |
| author_facet | Benjamin M. Moy Abhishek Shenoy Leslie B. Aldrich |
| author_sort | Benjamin M. Moy |
| collection | DOAJ |
| description | Key Clinical Message Immunosuppression, malnutrition, and underlying infection can unmask obscure infections which can be challenging to identify. Early diagnosis and treatment of infections in immunosuppressed patients are essential due to high morbidity and mortality. Abstract The immunosuppressive effects of treatment for ulcerative colitis (UC), including chronic corticosteroids, anti‐TNF agents, and JAK inhibitors, can impact the spread of latent or obscure infections. Clinicians should have a low threshold for pursuing aggressive diagnostic and therapeutic intervention in patients who show signs of clinical deterioration while on immunosuppressing medications. Our unique case highlights an immunosuppressed patient with UC who developed Nocardiosis after initiation of upadacitinib while hospitalized for concurrent UC flare and Clostridium difficile infection. |
| first_indexed | 2024-03-13T09:38:26Z |
| format | Article |
| id | doaj.art-71a01773aef4450f8b31bcdddec17be4 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-13T09:38:26Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-71a01773aef4450f8b31bcdddec17be42023-05-25T05:58:40ZengWileyClinical Case Reports2050-09042023-05-01115n/an/a10.1002/ccr3.7362A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinibBenjamin M. Moy0Abhishek Shenoy1Leslie B. Aldrich2University of Michigan Medical School Ann Arbor Michigan USADivision of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine Ann Arbor Michigan USADivision of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine Ann Arbor Michigan USAKey Clinical Message Immunosuppression, malnutrition, and underlying infection can unmask obscure infections which can be challenging to identify. Early diagnosis and treatment of infections in immunosuppressed patients are essential due to high morbidity and mortality. Abstract The immunosuppressive effects of treatment for ulcerative colitis (UC), including chronic corticosteroids, anti‐TNF agents, and JAK inhibitors, can impact the spread of latent or obscure infections. Clinicians should have a low threshold for pursuing aggressive diagnostic and therapeutic intervention in patients who show signs of clinical deterioration while on immunosuppressing medications. Our unique case highlights an immunosuppressed patient with UC who developed Nocardiosis after initiation of upadacitinib while hospitalized for concurrent UC flare and Clostridium difficile infection.https://doi.org/10.1002/ccr3.7362CrohnsIBDimmunosuppressionJAK inhibitorsNocardia |
| spellingShingle | Benjamin M. Moy Abhishek Shenoy Leslie B. Aldrich A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib Clinical Case Reports Crohns IBD immunosuppression JAK inhibitors Nocardia |
| title | A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib |
| title_full | A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib |
| title_fullStr | A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib |
| title_full_unstemmed | A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib |
| title_short | A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib |
| title_sort | case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids infliximab and upadacitinib |
| topic | Crohns IBD immunosuppression JAK inhibitors Nocardia |
| url | https://doi.org/10.1002/ccr3.7362 |
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