Varicocele and testicular function
Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=659;epage=667;aulast=Pastuszak |
| _version_ | 1811212410964410368 |
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| author | Alexander W Pastuszak Run Wang |
| author_facet | Alexander W Pastuszak Run Wang |
| author_sort | Alexander W Pastuszak |
| collection | DOAJ |
| description | Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on couples′ fertility. The relationship between varicocele and testicular endocrine function, while known for some time based on histologic evaluation, has become more apparent in the clinical setting with a growing link between varicocele and hypogonadism. Finally, in the pediatric setting, while future study will clarify the impact of varicocele on fertility and testicular function, recent work supports a parallel effect of varicocele in adolescents and adults, suggesting a re-evaluation of current treatment approaches in light of the progressive nature of the condition and potential increased risk of future disease. |
| first_indexed | 2024-04-12T05:28:56Z |
| format | Article |
| id | doaj.art-71a39e0c26f64d48880a6ae79d82ae4d |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-04-12T05:28:56Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-71a39e0c26f64d48880a6ae79d82ae4d2022-12-22T03:46:10ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-01-0117465966710.4103/1008-682X.153539Varicocele and testicular functionAlexander W PastuszakRun WangTesticular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on couples′ fertility. The relationship between varicocele and testicular endocrine function, while known for some time based on histologic evaluation, has become more apparent in the clinical setting with a growing link between varicocele and hypogonadism. Finally, in the pediatric setting, while future study will clarify the impact of varicocele on fertility and testicular function, recent work supports a parallel effect of varicocele in adolescents and adults, suggesting a re-evaluation of current treatment approaches in light of the progressive nature of the condition and potential increased risk of future disease.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=659;epage=667;aulast=Pastuszakgene regulationMusashiMusashi-1Musashi-2posttranscriptional controlRNA binding proteinsspermatogenesissplicingtestistranslationcell fatecell stressimportinkaryopherinnucleocytoplasmic transportspermatidspermatocytespermatogenesisartificial inseminationbiomarkerfertilityfertilizationflow cytometryinfertilitynanotechnologyoocyte activationPostacrosomal Sheath WWI Domain Binding ProteinspermSPTRX3thioredoxinubiquitinATP binding cassette transportersalbuminhigh-density lipoproteinlipid raftsmembrane fluiditymembrane microdomainsmembrane packingoxysterolsreverse cholesterol transportsterol transporterseggfertilizationheat shock protein A2molecular chaperonespermsperm-egg interactionsdehydrogenasesoxidasesperoxiredoxinsreactive oxygen speciesspermatozoathiolsthioredoxinsantigen-presenting cellsautoimmunitydendritic cellsepididymismacrophagesperipheral tolerancesperm maturationspermatozoagenomicsmale infertilityproteomicssperm chromatinsperm epigeneticssperm DNA damagepaternal genomeoffspringinfertilitychemotaxisrheotaxissperm behaviorsperm motilitythermotaxisapoptosisreactive oxygen speciessperm capacitationconservationcryobiologyendangered speciesmale fertilityspermatozoablood-testis barrierectoplasmic specializationezrinspermatogenesistestishypogonadismLeydig cellmale fertilityoxidative stressSertoli cellultramorphologyvaricocele |
| spellingShingle | Alexander W Pastuszak Run Wang Varicocele and testicular function Asian Journal of Andrology gene regulation Musashi Musashi-1 Musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation cell fate cell stress importin karyopherin nucleocytoplasmic transport spermatid spermatocyte spermatogenesis artificial insemination biomarker fertility fertilization flow cytometry infertility nanotechnology oocyte activation Postacrosomal Sheath WWI Domain Binding Protein sperm SPTRX3 thioredoxin ubiquitin ATP binding cassette transporters albumin high-density lipoprotein lipid rafts membrane fluidity membrane microdomains membrane packing oxysterols reverse cholesterol transport sterol transporters egg fertilization heat shock protein A2 molecular chaperone sperm sperm-egg interactions dehydrogenases oxidases peroxiredoxins reactive oxygen species spermatozoa thiols thioredoxins antigen-presenting cells autoimmunity dendritic cells epididymis macrophages peripheral tolerance sperm maturation spermatozoa genomics male infertility proteomics sperm chromatin sperm epigenetics sperm DNA damage paternal genome offspring infertility chemotaxis rheotaxis sperm behavior sperm motility thermotaxis apoptosis reactive oxygen species sperm capacitation conservation cryobiology endangered species male fertility spermatozoa blood-testis barrier ectoplasmic specialization ezrin spermatogenesis testis hypogonadism Leydig cell male fertility oxidative stress Sertoli cell ultramorphology varicocele |
| title | Varicocele and testicular function |
| title_full | Varicocele and testicular function |
| title_fullStr | Varicocele and testicular function |
| title_full_unstemmed | Varicocele and testicular function |
| title_short | Varicocele and testicular function |
| title_sort | varicocele and testicular function |
| topic | gene regulation Musashi Musashi-1 Musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation cell fate cell stress importin karyopherin nucleocytoplasmic transport spermatid spermatocyte spermatogenesis artificial insemination biomarker fertility fertilization flow cytometry infertility nanotechnology oocyte activation Postacrosomal Sheath WWI Domain Binding Protein sperm SPTRX3 thioredoxin ubiquitin ATP binding cassette transporters albumin high-density lipoprotein lipid rafts membrane fluidity membrane microdomains membrane packing oxysterols reverse cholesterol transport sterol transporters egg fertilization heat shock protein A2 molecular chaperone sperm sperm-egg interactions dehydrogenases oxidases peroxiredoxins reactive oxygen species spermatozoa thiols thioredoxins antigen-presenting cells autoimmunity dendritic cells epididymis macrophages peripheral tolerance sperm maturation spermatozoa genomics male infertility proteomics sperm chromatin sperm epigenetics sperm DNA damage paternal genome offspring infertility chemotaxis rheotaxis sperm behavior sperm motility thermotaxis apoptosis reactive oxygen species sperm capacitation conservation cryobiology endangered species male fertility spermatozoa blood-testis barrier ectoplasmic specialization ezrin spermatogenesis testis hypogonadism Leydig cell male fertility oxidative stress Sertoli cell ultramorphology varicocele |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=659;epage=667;aulast=Pastuszak |
| work_keys_str_mv | AT alexanderwpastuszak varicoceleandtesticularfunction AT runwang varicoceleandtesticularfunction |