HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated...
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MDPI AG
2021-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/22/5833 |
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| author | Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra |
| author_facet | Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra |
| author_sort | Geok Wee Tan |
| collection | DOAJ |
| description | Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated with HLA susceptibility alleles. A meta-analysis was carried out to identify consistent protective and risk HLA alleles in a combined cohort of 839 cHL patients from the Netherlands and the United Kingdom. Tumour cell HLA expression was studied in 338 cHL cases from these two cohorts and correlated to the presence of specific susceptibility HLA alleles. Carriers of the HLA-DRB1*07 protective allele frequently lost HLA class II expression in cHL overall. Patients carrying the HLA-DRB1*15/16 (DR2) risk allele retained HLA class II expression in EBV− cHL and patients with the HLA-B*37 risk allele retained HLA class I expression more frequently than non-carriers in EBV+ cHL. The other susceptibility alleles showed no significant differences in expression. Thus, HLA expression by tumour cells is associated with a subset of the protective and risk alleles. This strongly suggests that HLA associations in cHL are related to peptide binding capacities of specific HLA alleles. |
| first_indexed | 2024-03-10T05:38:20Z |
| format | Article |
| id | doaj.art-71a4121273e74fb4b2f653f84a47405b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:38:20Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-71a4121273e74fb4b2f653f84a47405b2023-11-22T22:43:58ZengMDPI AGCancers2072-66942021-11-011322583310.3390/cancers13225833HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma PatientsGeok Wee Tan0Peijia Jiang1Ilja M. Nolte2Kushi Kushekhar3Rianne N. Veenstra4Bouke G. Hepkema5Ruth F. Jarrett6Anke van den Berg7Arjan Diepstra8Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UKDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsSeveral human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated with HLA susceptibility alleles. A meta-analysis was carried out to identify consistent protective and risk HLA alleles in a combined cohort of 839 cHL patients from the Netherlands and the United Kingdom. Tumour cell HLA expression was studied in 338 cHL cases from these two cohorts and correlated to the presence of specific susceptibility HLA alleles. Carriers of the HLA-DRB1*07 protective allele frequently lost HLA class II expression in cHL overall. Patients carrying the HLA-DRB1*15/16 (DR2) risk allele retained HLA class II expression in EBV− cHL and patients with the HLA-B*37 risk allele retained HLA class I expression more frequently than non-carriers in EBV+ cHL. The other susceptibility alleles showed no significant differences in expression. Thus, HLA expression by tumour cells is associated with a subset of the protective and risk alleles. This strongly suggests that HLA associations in cHL are related to peptide binding capacities of specific HLA alleles.https://www.mdpi.com/2072-6694/13/22/5833cHLsusceptibilityHLA expressionEBV |
| spellingShingle | Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients Cancers cHL susceptibility HLA expression EBV |
| title | HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients |
| title_full | HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients |
| title_fullStr | HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients |
| title_full_unstemmed | HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients |
| title_short | HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients |
| title_sort | hla expression in relation to hla type in classic hodgkin lymphoma patients |
| topic | cHL susceptibility HLA expression EBV |
| url | https://www.mdpi.com/2072-6694/13/22/5833 |
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