Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
Abstract Background Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. Methods Two hundred and seventy patients with ISSNHL were included. Among them, 180...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.909 |
| _version_ | 1811182664695152640 |
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| author | Yongzhen Wu Zijun Song Yi Wang Hui Zhao Tongli Ren Jianghua Jing Na Gao Liang Qiao Jing Wang |
| author_facet | Yongzhen Wu Zijun Song Yi Wang Hui Zhao Tongli Ren Jianghua Jing Na Gao Liang Qiao Jing Wang |
| author_sort | Yongzhen Wu |
| collection | DOAJ |
| description | Abstract Background Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. Methods Two hundred and seventy patients with ISSNHL were included. Among them, 180 were treated with ITS and standard medical treatment (SMT) and the other 90 received SMT along. The hearing threshold before and after salvage treatment were compared. The relationship between the salvage starting time and hearing recovery was analyzed. Results The hearing of ITS group improved more than that of the SMT group in all frequency bands. The effect of both strategies decreases with the delay of the starting time. ITS can improve hearing even if being administrated 5 weeks after onset while SMT failed after 3 weeks. Conclusion Patients with profound ISSNHL can obtain extra hearing recovery from salvage ITS. The earlier salvage starts, the greater the patient benefits. |
| first_indexed | 2024-04-11T09:35:40Z |
| format | Article |
| id | doaj.art-71a50b5d57f948f690cb8db93a23c517 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-11T09:35:40Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-71a50b5d57f948f690cb8db93a23c5172022-12-22T04:31:44ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-10-01751559156710.1002/lio2.909Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing lossYongzhen Wu0Zijun Song1Yi Wang2Hui Zhao3Tongli Ren4Jianghua Jing5Na Gao6Liang Qiao7Jing Wang8Department of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaDepartment of Gastroenterology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Otology and Skull Base Surgery Eye Ear Nose & Throat Hospital, Fudan University Shanghai ChinaAbstract Background Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. Methods Two hundred and seventy patients with ISSNHL were included. Among them, 180 were treated with ITS and standard medical treatment (SMT) and the other 90 received SMT along. The hearing threshold before and after salvage treatment were compared. The relationship between the salvage starting time and hearing recovery was analyzed. Results The hearing of ITS group improved more than that of the SMT group in all frequency bands. The effect of both strategies decreases with the delay of the starting time. ITS can improve hearing even if being administrated 5 weeks after onset while SMT failed after 3 weeks. Conclusion Patients with profound ISSNHL can obtain extra hearing recovery from salvage ITS. The earlier salvage starts, the greater the patient benefits.https://doi.org/10.1002/lio2.909idiopathic sudden sensorineural hearing lossintratympanic steroidslocally weighted regressionpure tone audiometrysalvage treatment |
| spellingShingle | Yongzhen Wu Zijun Song Yi Wang Hui Zhao Tongli Ren Jianghua Jing Na Gao Liang Qiao Jing Wang Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss Laryngoscope Investigative Otolaryngology idiopathic sudden sensorineural hearing loss intratympanic steroids locally weighted regression pure tone audiometry salvage treatment |
| title | Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| title_full | Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| title_fullStr | Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| title_full_unstemmed | Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| title_short | Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| title_sort | optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss |
| topic | idiopathic sudden sensorineural hearing loss intratympanic steroids locally weighted regression pure tone audiometry salvage treatment |
| url | https://doi.org/10.1002/lio2.909 |
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