Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema
AIM: To investigate for any detectable change in sub-foveal choroidal thickness following intravitreal injections of Ranibizumab or Aflibercept in patients with central involving diabetic macula edema(DME), evidenced by optical coherence tomography(OCT).METHODS: Totally 17 patients with central invo...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2022-01-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/1/202201001.pdf |
| _version_ | 1819100251762458624 |
|---|---|
| author | Jia Cherng Chong Hanizasurana Hashim Tajunisah Iqbal |
| author_facet | Jia Cherng Chong Hanizasurana Hashim Tajunisah Iqbal |
| author_sort | Jia Cherng Chong |
| collection | DOAJ |
| description | AIM: To investigate for any detectable change in sub-foveal choroidal thickness following intravitreal injections of Ranibizumab or Aflibercept in patients with central involving diabetic macula edema(DME), evidenced by optical coherence tomography(OCT).METHODS: Totally 17 patients with central involving DME who required and agreed to intravitreal anti-VEGF injection were invited to be the subject of this study. These injection-naive subjects were undergone three loading doses of monthly intravitreal anti-VEGF(Ranibizumab 0.5 mg/0.05 mL for 9 patients or Aflibercept 2 mg/0.05 mL for 8 patients)injection, and a clinic review appointment 1mo after the third injection. The changes of foveal choroidal thickness, visual acuity and central retinal thickness at 1mo were observed before and after treatment in 2 groups by enhanced depth image-optical coherence tomography(EDI-OCT). RESULTS: We recorded a significant sub-foveal choroidal thinning and vision improvement after three loading doses of anti-VEGF(all P<0.05). The thinning effect between Ranibizumab and Aflibercept group was insignificant(all P>0.05). There was no significant correlation between pre-treatment sub-foveal choroidal thickness and vision improvement(rs=-0.269, P=0.296). There was also no significant correlation between choroidal thickness changes with vision improvement, central retinal thickness change and age of subjects(all P >0.05).CONCLUSION: Intravitreal Ranibizumab and Aflibercept injections both leads to significant sub-foveal choroidal thinning in DME subjects. It was accompanied with significant vision improvement with no evidence of immediate detrimental effect of choroidal thinning. Future research with a longer study duration would help in establishing the duration and long term effect of choroidal thinning. |
| first_indexed | 2024-12-22T00:59:49Z |
| format | Article |
| id | doaj.art-71a6d157c25e4366a333f31090ae1d3e |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-22T00:59:49Z |
| publishDate | 2022-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-71a6d157c25e4366a333f31090ae1d3e2022-12-21T18:44:14ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-01-012211810.3980/j.issn.1672-5123.2022.1.01202201001Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edemaJia Cherng Chong0Hanizasurana Hashim1Tajunisah Iqbal2Department of Ophthalmology, University of Malaya, Kuala Lumpur 50603, Malaysia; Department of Ophthalmology, Hospital Selayang, Selangor 68100, Malaysia; University of Malaya Eye Research Centre(UMERC), Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Ophthalmology, Hospital Selayang, Selangor 68100, MalaysiaDepartment of Ophthalmology, University of Malaya, Kuala Lumpur 50603, Malaysia; University of Malaya Eye Research Centre(UMERC), Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaAIM: To investigate for any detectable change in sub-foveal choroidal thickness following intravitreal injections of Ranibizumab or Aflibercept in patients with central involving diabetic macula edema(DME), evidenced by optical coherence tomography(OCT).METHODS: Totally 17 patients with central involving DME who required and agreed to intravitreal anti-VEGF injection were invited to be the subject of this study. These injection-naive subjects were undergone three loading doses of monthly intravitreal anti-VEGF(Ranibizumab 0.5 mg/0.05 mL for 9 patients or Aflibercept 2 mg/0.05 mL for 8 patients)injection, and a clinic review appointment 1mo after the third injection. The changes of foveal choroidal thickness, visual acuity and central retinal thickness at 1mo were observed before and after treatment in 2 groups by enhanced depth image-optical coherence tomography(EDI-OCT). RESULTS: We recorded a significant sub-foveal choroidal thinning and vision improvement after three loading doses of anti-VEGF(all P<0.05). The thinning effect between Ranibizumab and Aflibercept group was insignificant(all P>0.05). There was no significant correlation between pre-treatment sub-foveal choroidal thickness and vision improvement(rs=-0.269, P=0.296). There was also no significant correlation between choroidal thickness changes with vision improvement, central retinal thickness change and age of subjects(all P >0.05).CONCLUSION: Intravitreal Ranibizumab and Aflibercept injections both leads to significant sub-foveal choroidal thinning in DME subjects. It was accompanied with significant vision improvement with no evidence of immediate detrimental effect of choroidal thinning. Future research with a longer study duration would help in establishing the duration and long term effect of choroidal thinning.http://ies.ijo.cn/cn_publish/2022/1/202201001.pdfanti-vegfafliberceptchoroidal thicknessdiabetic retinopathydiabetic macula edemaranibizumaboptical coherence tomographyenhanced depth image-optical coherence tomography |
| spellingShingle | Jia Cherng Chong Hanizasurana Hashim Tajunisah Iqbal Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema Guoji Yanke Zazhi anti-vegf aflibercept choroidal thickness diabetic retinopathy diabetic macula edema ranibizumab optical coherence tomography enhanced depth image-optical coherence tomography |
| title | Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema |
| title_full | Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema |
| title_fullStr | Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema |
| title_full_unstemmed | Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema |
| title_short | Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema |
| title_sort | effect of intravitreal anti vegf injection on choroidal thickness in patients with diabetic macula edema |
| topic | anti-vegf aflibercept choroidal thickness diabetic retinopathy diabetic macula edema ranibizumab optical coherence tomography enhanced depth image-optical coherence tomography |
| url | http://ies.ijo.cn/cn_publish/2022/1/202201001.pdf |
| work_keys_str_mv | AT jiacherngchong effectofintravitrealantivegfinjectiononchoroidalthicknessinpatientswithdiabeticmaculaedema AT hanizasuranahashim effectofintravitrealantivegfinjectiononchoroidalthicknessinpatientswithdiabeticmaculaedema AT tajunisahiqbal effectofintravitrealantivegfinjectiononchoroidalthicknessinpatientswithdiabeticmaculaedema |