Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials
Background: The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE versus TACE alone and quan...
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
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Frontiers Media S.A.
2024-06-01
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| Sarja: | Frontiers in Pharmacology |
| Aiheet: | |
| Linkit: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1337179/full |
| _version_ | 1827215631532949504 |
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| author | Zhi-Hai Wu Zhi-Hai Wu Hai-Feng Zhang Jun-Yan Li Yi-Rui Diao Man-Jing Huang Dong-Yang Gao Chang-Hao Liang Zhi-Qiang Luo |
| author_facet | Zhi-Hai Wu Zhi-Hai Wu Hai-Feng Zhang Jun-Yan Li Yi-Rui Diao Man-Jing Huang Dong-Yang Gao Chang-Hao Liang Zhi-Qiang Luo |
| author_sort | Zhi-Hai Wu |
| collection | DOAJ |
| description | Background: The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE versus TACE alone and quantifies the differences between these two treatment methods.Methods: A systematic search was conducted in multiple databases including PubMed, Cochrane, CNKI, and Wanfang, until 1 July 2023. Meta-analysis was conducted, and the results were presented as mean difference (MD), risk ratio (RR), and 95% confidence intervals (CI).Results: The search yielded 11 RCTs, with a combined sample size of 1054 patients. Meta-analysis revealed that BJO-assisted TACE exhibited superior outcomes compared to standalone TACE. Specific data revealed that BJO-assisted TACE improves clinical benefit rate by 22% [RR = 1.22, 95% CI (1.15, 1.30)], increases the number of people with improved quality of life by 32%, resulting in an average score improvement of 9.53 points [RR = 1.32, 95% CI (1.22, 1.43); MD = 9.53, 95% CI (6.95, 12.10)]. Furthermore, AFP improvement rate improved significantly by approximately 134% [RR = 2.34, 95% CI (1.58, 3.46)], accompanied by notable improvements in liver function indicators, with an average reduction of 27.19 U/L in AST [MD = −27.19, 95% CI (−40.36, −14.02)], 20.77 U/L in ALT [MD = −20.77, 95% CI (−39.46, −2.08)], 12.17 μmol/L in TBIL [MD = −12.17, 95% CI (−19.38, −4.97)], and a decrease of 43.72 pg/mL in VEGF [MD = −43.72, 95% CI (−63.29, −24.15)]. Most importantly, there was a 29% reduction in the occurrence of adverse reactions [RR = 0.71, 95% CI (0.60, 0.84)].Conclusion: These findings indicate that BJO-assisted TACE may be considered as a potentially beneficial treatment option for liver cancer patients when compared to standalone TACE. It appears to contribute to improved treatment outcomes, enhanced quality of life, and potentially reduced adverse reactions, suggesting it warrants further investigation as a promising approach for liver cancer treatment.Systematic Review Registration: identifier CRD42023428948 |
| first_indexed | 2025-03-21T14:50:18Z |
| format | Article |
| id | doaj.art-71a7ba57ff0e4b57a98a8c20b7e7d43b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2025-03-21T14:50:18Z |
| publishDate | 2024-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-71a7ba57ff0e4b57a98a8c20b7e7d43b2024-06-21T07:50:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-06-011510.3389/fphar.2024.13371791337179Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trialsZhi-Hai Wu0Zhi-Hai Wu1Hai-Feng Zhang2Jun-Yan Li3Yi-Rui Diao4Man-Jing Huang5Dong-Yang Gao6Chang-Hao Liang7Zhi-Qiang Luo8State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaSchool of Information Technology, Monash University Malaysia, Subang Jaya, MalaysiaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaBackground: The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE versus TACE alone and quantifies the differences between these two treatment methods.Methods: A systematic search was conducted in multiple databases including PubMed, Cochrane, CNKI, and Wanfang, until 1 July 2023. Meta-analysis was conducted, and the results were presented as mean difference (MD), risk ratio (RR), and 95% confidence intervals (CI).Results: The search yielded 11 RCTs, with a combined sample size of 1054 patients. Meta-analysis revealed that BJO-assisted TACE exhibited superior outcomes compared to standalone TACE. Specific data revealed that BJO-assisted TACE improves clinical benefit rate by 22% [RR = 1.22, 95% CI (1.15, 1.30)], increases the number of people with improved quality of life by 32%, resulting in an average score improvement of 9.53 points [RR = 1.32, 95% CI (1.22, 1.43); MD = 9.53, 95% CI (6.95, 12.10)]. Furthermore, AFP improvement rate improved significantly by approximately 134% [RR = 2.34, 95% CI (1.58, 3.46)], accompanied by notable improvements in liver function indicators, with an average reduction of 27.19 U/L in AST [MD = −27.19, 95% CI (−40.36, −14.02)], 20.77 U/L in ALT [MD = −20.77, 95% CI (−39.46, −2.08)], 12.17 μmol/L in TBIL [MD = −12.17, 95% CI (−19.38, −4.97)], and a decrease of 43.72 pg/mL in VEGF [MD = −43.72, 95% CI (−63.29, −24.15)]. Most importantly, there was a 29% reduction in the occurrence of adverse reactions [RR = 0.71, 95% CI (0.60, 0.84)].Conclusion: These findings indicate that BJO-assisted TACE may be considered as a potentially beneficial treatment option for liver cancer patients when compared to standalone TACE. It appears to contribute to improved treatment outcomes, enhanced quality of life, and potentially reduced adverse reactions, suggesting it warrants further investigation as a promising approach for liver cancer treatment.Systematic Review Registration: identifier CRD42023428948https://www.frontiersin.org/articles/10.3389/fphar.2024.1337179/fullliver cancertransarterial chemoembolization (TACE)brucea javanica oil (BJO)efficacymeta-analysis |
| spellingShingle | Zhi-Hai Wu Zhi-Hai Wu Hai-Feng Zhang Jun-Yan Li Yi-Rui Diao Man-Jing Huang Dong-Yang Gao Chang-Hao Liang Zhi-Qiang Luo Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials Frontiers in Pharmacology liver cancer transarterial chemoembolization (TACE) brucea javanica oil (BJO) efficacy meta-analysis |
| title | Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | effectiveness and safety of brucea javanica oil assisted tace versus tace in the treatment of liver cancer a systematic review and meta analysis of randomized controlled trials |
| topic | liver cancer transarterial chemoembolization (TACE) brucea javanica oil (BJO) efficacy meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1337179/full |
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