Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes
Abstract Aims/Introduction The clinical significance of age‐related biomarkers in patients with diabetes has not been fully elucidated. In this study, we aimed to establish models to predict the progression of aging in patients with diabetes using biomarkers. Materials and Methods This single‐center...
| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artikel |
| Språk: | English |
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Wiley
2024-11-01
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| Serie: | Journal of Diabetes Investigation |
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| Länkar: | https://doi.org/10.1111/jdi.14286 |
| _version_ | 1827011142069780480 |
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| author | Kotaro Umamoto Ryotaro Bouchi Kotaro Soeda Shosuke Satake Tohru Hosoyama Mitsuru Ohsugi Kohjiro Ueki Hiroshi Kajio |
| author_facet | Kotaro Umamoto Ryotaro Bouchi Kotaro Soeda Shosuke Satake Tohru Hosoyama Mitsuru Ohsugi Kohjiro Ueki Hiroshi Kajio |
| author_sort | Kotaro Umamoto |
| collection | DOAJ |
| description | Abstract Aims/Introduction The clinical significance of age‐related biomarkers in patients with diabetes has not been fully elucidated. In this study, we aimed to establish models to predict the progression of aging in patients with diabetes using biomarkers. Materials and Methods This single‐center, retrospective cohort study included 115 Japanese patients with diabetes aged ≥60 years. Age‐related adverse health outcomes were defined as emergency hospitalization, any increase in the level of nursing care certification, admission to a nursing home or death. The associations of age‐related biomarker levels (adiponectin, growth differentiation factor 15 [GDF15], C‐X‐C motif chemokine ligand 9 and apelin) and clinical indicators with age‐related adverse health outcomes were evaluated. Factors that predominantly influenced the occurrence of age‐related adverse health outcomes were explored using the Cox proportional hazards model. Results The mean age of the 115 participants was 73 years, 50.6% were men, the mean body mass index and hemoglobin A1c level were 25.3 kg/m2 and 9.79%, respectively. There were 26 age‐related adverse health outcomes during the study period (median 1.93, range 0–4.65 years). In a model combining clinical indicators and biomarkers, including the Barthel Index, GDF15 and adiponectin, the occurrence of age‐related adverse health outcomes was found to be significantly associated with GDF15 and Barthel Index. The group with both GDF15 and adiponectin levels higher than the median proved to be significantly higher than the group with both lower. Conclusions The measurement of GDF15 and adiponectin levels and the Barthel Index might be useful for predicting age‐related adverse health outcomes in patients with diabetes. |
| first_indexed | 2025-02-18T13:16:45Z |
| format | Article |
| id | doaj.art-71a7bf8f12e44e16a357b45fa472df1f |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2025-02-18T13:16:45Z |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-71a7bf8f12e44e16a357b45fa472df1f2024-11-01T05:42:40ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-11-0115111675168310.1111/jdi.14286Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetesKotaro Umamoto0Ryotaro Bouchi1Kotaro Soeda2Shosuke Satake3Tohru Hosoyama4Mitsuru Ohsugi5Kohjiro Ueki6Hiroshi Kajio7Department of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDiabetes Research Center, Research Institute National Center for Global Health and Medicine Tokyo JapanDepartment of Geriatric Medicine National Center for Geriatrics and Gerontology Aichi JapanDepartment of Musculoskeletal Disease, The Geroscience Research Center National Center for Geriatrics and Gerontology Aichi JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanAbstract Aims/Introduction The clinical significance of age‐related biomarkers in patients with diabetes has not been fully elucidated. In this study, we aimed to establish models to predict the progression of aging in patients with diabetes using biomarkers. Materials and Methods This single‐center, retrospective cohort study included 115 Japanese patients with diabetes aged ≥60 years. Age‐related adverse health outcomes were defined as emergency hospitalization, any increase in the level of nursing care certification, admission to a nursing home or death. The associations of age‐related biomarker levels (adiponectin, growth differentiation factor 15 [GDF15], C‐X‐C motif chemokine ligand 9 and apelin) and clinical indicators with age‐related adverse health outcomes were evaluated. Factors that predominantly influenced the occurrence of age‐related adverse health outcomes were explored using the Cox proportional hazards model. Results The mean age of the 115 participants was 73 years, 50.6% were men, the mean body mass index and hemoglobin A1c level were 25.3 kg/m2 and 9.79%, respectively. There were 26 age‐related adverse health outcomes during the study period (median 1.93, range 0–4.65 years). In a model combining clinical indicators and biomarkers, including the Barthel Index, GDF15 and adiponectin, the occurrence of age‐related adverse health outcomes was found to be significantly associated with GDF15 and Barthel Index. The group with both GDF15 and adiponectin levels higher than the median proved to be significantly higher than the group with both lower. Conclusions The measurement of GDF15 and adiponectin levels and the Barthel Index might be useful for predicting age‐related adverse health outcomes in patients with diabetes.https://doi.org/10.1111/jdi.14286AgingBiomarkerDiabetes |
| spellingShingle | Kotaro Umamoto Ryotaro Bouchi Kotaro Soeda Shosuke Satake Tohru Hosoyama Mitsuru Ohsugi Kohjiro Ueki Hiroshi Kajio Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes Journal of Diabetes Investigation Aging Biomarker Diabetes |
| title | Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes |
| title_full | Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes |
| title_fullStr | Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes |
| title_full_unstemmed | Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes |
| title_short | Association of biomarkers and Barthel Index with occurrence of age‐related adverse health outcomes in individuals with diabetes |
| title_sort | association of biomarkers and barthel index with occurrence of age related adverse health outcomes in individuals with diabetes |
| topic | Aging Biomarker Diabetes |
| url | https://doi.org/10.1111/jdi.14286 |
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