A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.

A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.

Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic reticulum (ER) stress leads to apoptosis through the upregulation of a subset of pr...

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Bibliographic Details
Main Authors: Sebastián Zamorano, Diego Rojas-Rivera, Fernanda Lisbona, Valentina Parra, Felipe A Court, Rosario Villegas, Emily H Cheng, Stanley J Korsmeyer, Sergio Lavandero, Claudio Hetz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3373601?pdf=render

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