A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications
Cold atmospheric plasmas (CAPs) used in plasma medicine have shown great potential in various aspects including wound healing, dermatology, cancer therapy, etc. It is one of the important issues to determine the plasma dosage in plasma medicine because it dominates the specific plasma treatment resu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/23/11135 |
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| author | Jing Li Lu-Xiang Zhao Tao He Wei-Wu Dong Yue Yuan Xiang Zhao Xin-Yi Chen Na Zhang Zhi-Fan Zou Yu Zhang He-Ping Li |
| author_facet | Jing Li Lu-Xiang Zhao Tao He Wei-Wu Dong Yue Yuan Xiang Zhao Xin-Yi Chen Na Zhang Zhi-Fan Zou Yu Zhang He-Ping Li |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Cold atmospheric plasmas (CAPs) used in plasma medicine have shown great potential in various aspects including wound healing, dermatology, cancer therapy, etc. It is one of the important issues to determine the plasma dosage in plasma medicine because it dominates the specific plasma treatment results. However, the multi-process interactions between CAPs and biological materials make it rather challenging to give an accurate and versatile definition for plasma dosage. In this study, the ratio of the discharge energy to the number of the treated in vitro kidney cells (mJ/cell) was employed as the unit of the plasma dosage. Additionally, inspired by basic knowledge of pharmacy, the median lethal dose (LD<sub>50</sub>) was employed to help estimate the plasma dosage. The experimental results show that the value of LD<sub>50</sub> using the newly designed CAP Bio-Med Platform for the kidney cells is 34.67 mJ/cell. This biology-based method has the advantages of easy operation, independence of specific CAP sources, and also independence of complex interactions between CAPs and the treated biological targets, and consequently, may provide a new direction to quantitatively define the plasma dosage in various plasma medical applications. |
| first_indexed | 2024-03-10T04:58:11Z |
| format | Article |
| id | doaj.art-71aab9a40dab4755975f140e8a8db3d0 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T04:58:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-71aab9a40dab4755975f140e8a8db3d02023-11-23T02:03:05ZengMDPI AGApplied Sciences2076-34172021-11-0111231113510.3390/app112311135A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical ApplicationsJing Li0Lu-Xiang Zhao1Tao He2Wei-Wu Dong3Yue Yuan4Xiang Zhao5Xin-Yi Chen6Na Zhang7Zhi-Fan Zou8Yu Zhang9He-Ping Li10Department of Engineering Physics, Tsinghua University, Beijing 100084, ChinaSchool of Mechanical Engineering, Tsinghua University, Beijing 100084, ChinaSchool of Medicine, Tsinghua University, Beijing 100084, ChinaCollege of Mechanical Engineering, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Pharmaceutical Science, Tsinghua University, Beijing 100084, ChinaSchool of Mechanical Engineering, Tsinghua University, Beijing 100084, ChinaSchool of Pharmaceutical Science, Tsinghua University, Beijing 100084, ChinaSchool of Pharmaceutical Science, Tsinghua University, Beijing 100084, ChinaSchool of Medicine, Tsinghua University, Beijing 100084, ChinaSchool of Medicine, Tsinghua University, Beijing 100084, ChinaDepartment of Engineering Physics, Tsinghua University, Beijing 100084, ChinaCold atmospheric plasmas (CAPs) used in plasma medicine have shown great potential in various aspects including wound healing, dermatology, cancer therapy, etc. It is one of the important issues to determine the plasma dosage in plasma medicine because it dominates the specific plasma treatment results. However, the multi-process interactions between CAPs and biological materials make it rather challenging to give an accurate and versatile definition for plasma dosage. In this study, the ratio of the discharge energy to the number of the treated in vitro kidney cells (mJ/cell) was employed as the unit of the plasma dosage. Additionally, inspired by basic knowledge of pharmacy, the median lethal dose (LD<sub>50</sub>) was employed to help estimate the plasma dosage. The experimental results show that the value of LD<sub>50</sub> using the newly designed CAP Bio-Med Platform for the kidney cells is 34.67 mJ/cell. This biology-based method has the advantages of easy operation, independence of specific CAP sources, and also independence of complex interactions between CAPs and the treated biological targets, and consequently, may provide a new direction to quantitatively define the plasma dosage in various plasma medical applications.https://www.mdpi.com/2076-3417/11/23/11135plasma dosagecold atmospheric plasmaplasma medicinein vitro cell culture |
| spellingShingle | Jing Li Lu-Xiang Zhao Tao He Wei-Wu Dong Yue Yuan Xiang Zhao Xin-Yi Chen Na Zhang Zhi-Fan Zou Yu Zhang He-Ping Li A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications Applied Sciences plasma dosage cold atmospheric plasma plasma medicine in vitro cell culture |
| title | A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications |
| title_full | A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications |
| title_fullStr | A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications |
| title_full_unstemmed | A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications |
| title_short | A Novel Method for Estimating the Dosage of Cold Atmospheric Plasmas in Plasma Medical Applications |
| title_sort | novel method for estimating the dosage of cold atmospheric plasmas in plasma medical applications |
| topic | plasma dosage cold atmospheric plasma plasma medicine in vitro cell culture |
| url | https://www.mdpi.com/2076-3417/11/23/11135 |
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