The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. Howev...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/12/2457 |
| _version_ | 1797456154244153344 |
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| author | Andras Bikov Silvano Dragonieri Balazs Csoma Carmen Mazzuca Panaiotis Finamore Giulia Rocchi Lorenza Putignani Michele Guarino Simone Scarlata |
| author_facet | Andras Bikov Silvano Dragonieri Balazs Csoma Carmen Mazzuca Panaiotis Finamore Giulia Rocchi Lorenza Putignani Michele Guarino Simone Scarlata |
| author_sort | Andras Bikov |
| collection | DOAJ |
| description | The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes. |
| first_indexed | 2024-03-09T16:04:15Z |
| format | Article |
| id | doaj.art-71ab4b06a59946e5903846bf5a895587 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:04:15Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-71ab4b06a59946e5903846bf5a8955872023-11-24T16:49:25ZengMDPI AGMicroorganisms2076-26072022-12-011012245710.3390/microorganisms10122457The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep ApnoeaAndras Bikov0Silvano Dragonieri1Balazs Csoma2Carmen Mazzuca3Panaiotis Finamore4Giulia Rocchi5Lorenza Putignani6Michele Guarino7Simone Scarlata8Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UKDepartment of Respiratory Diseases, University of Bari Aldo Moro, 11 Piazza G. Cesare, 70124 Bari, ItalyWythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UKUnit of Internal Medicine, Campus Bio-Medico University Hospital, 00128 Rome, ItalyUnit of Internal Medicine, Campus Bio-Medico University Hospital, 00128 Rome, ItalyDepartment of Science and Engineering for Human and the Environment, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Diagnostics and Laboratory Medicine, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyUnit of Gastroenterology, Campus Bio-Medico University Hospital, 00128 Rome, ItalyUnit of Internal Medicine, Campus Bio-Medico University Hospital, 00128 Rome, ItalyThe human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes.https://www.mdpi.com/2076-2607/10/12/2457microbiomegut microbiomebronchial asthmachronic obstructive pulmonary diseaseobstructive sleep apneainflammation |
| spellingShingle | Andras Bikov Silvano Dragonieri Balazs Csoma Carmen Mazzuca Panaiotis Finamore Giulia Rocchi Lorenza Putignani Michele Guarino Simone Scarlata The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea Microorganisms microbiome gut microbiome bronchial asthma chronic obstructive pulmonary disease obstructive sleep apnea inflammation |
| title | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
| title_full | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
| title_fullStr | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
| title_full_unstemmed | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
| title_short | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
| title_sort | role of gut bacteriome in asthma chronic obstructive pulmonary disease and obstructive sleep apnoea |
| topic | microbiome gut microbiome bronchial asthma chronic obstructive pulmonary disease obstructive sleep apnea inflammation |
| url | https://www.mdpi.com/2076-2607/10/12/2457 |
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