The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)
<i>Background and Objectives</i>: We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-ass...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/24/7732 |
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| author | Kazumasa Murase Makoto Kawase Shin Ebara Tomoyuki Tatenuma Takeshi Sasaki Yoshinori Ikehata Akinori Nakayama Masahiro Toide Tatsuaki Yoneda Kazushige Sakaguchi Jun Teishima Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Fumitaka Koga Shinji Urakami Takuya Koie |
| author_facet | Kazumasa Murase Makoto Kawase Shin Ebara Tomoyuki Tatenuma Takeshi Sasaki Yoshinori Ikehata Akinori Nakayama Masahiro Toide Tatsuaki Yoneda Kazushige Sakaguchi Jun Teishima Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Fumitaka Koga Shinji Urakami Takuya Koie |
| author_sort | Kazumasa Murase |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). <i>Materials and Methods</i>: A retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutes in Japan was conducted. This study enrolled 3195 patients. We focused on patients undergoing RARP who underwent the preoperative measurement of their inflammation-related parameters and who did not receive any neo- or adjuvant therapy. Data on the pre- and postoperative variables for the enrolled patients were obtained. The primary endpoint of this study was the association between BCR and the inflammation-related parameters after RARP. The secondary endpoint was the association between the inflammation-related parameters and the pathological diagnosis of PCa. <i>Results</i>: Data from 2429 patients with PCa who met the study’s eligibility criteria were analyzed. The median follow-up period was 25.1 months. The inflammation-related parameters were divided into two groups, and cutoff values were determined based on the receiver operating characteristics. There were no statistically significant differences in biochemical recurrence-free survival for any of the parameters. In the univariate analysis, the NLR was predictive of pathological T3 and lymphovascular invasion; however, there were no significant differences in the multivariate analysis. <i>Conclusions</i>: The inflammation-related parameters did not significantly affect the incidence of BCR, at least among patients with PCa who underwent RARP. |
| first_indexed | 2024-03-08T20:38:54Z |
| format | Article |
| id | doaj.art-71ac0944b87f434f9451bd3e0067b6eb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:38:54Z |
| publishDate | 2023-12-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-71ac0944b87f434f9451bd3e0067b6eb2023-12-22T14:17:35ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224773210.3390/jcm12247732The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)Kazumasa Murase0Makoto Kawase1Shin Ebara2Tomoyuki Tatenuma3Takeshi Sasaki4Yoshinori Ikehata5Akinori Nakayama6Masahiro Toide7Tatsuaki Yoneda8Kazushige Sakaguchi9Jun Teishima10Kazuhide Makiyama11Takahiro Inoue12Hiroshi Kitamura13Kazutaka Saito14Fumitaka Koga15Shinji Urakami16Takuya Koie17Department of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Urology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, JapanDepartment of Urology, Yokohama City University, Yokohama 236-0004, JapanDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Urology, University of Toyama, Toyama 930-0194, JapanDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, JapanDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, JapanDepartment of Urology, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, JapanDepartment of Urology, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Surgery, Division of Urology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Urology, Yokohama City University, Yokohama 236-0004, JapanDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Urology, University of Toyama, Toyama 930-0194, JapanDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, JapanDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, JapanDepartment of Urology, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan<i>Background and Objectives</i>: We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). <i>Materials and Methods</i>: A retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutes in Japan was conducted. This study enrolled 3195 patients. We focused on patients undergoing RARP who underwent the preoperative measurement of their inflammation-related parameters and who did not receive any neo- or adjuvant therapy. Data on the pre- and postoperative variables for the enrolled patients were obtained. The primary endpoint of this study was the association between BCR and the inflammation-related parameters after RARP. The secondary endpoint was the association between the inflammation-related parameters and the pathological diagnosis of PCa. <i>Results</i>: Data from 2429 patients with PCa who met the study’s eligibility criteria were analyzed. The median follow-up period was 25.1 months. The inflammation-related parameters were divided into two groups, and cutoff values were determined based on the receiver operating characteristics. There were no statistically significant differences in biochemical recurrence-free survival for any of the parameters. In the univariate analysis, the NLR was predictive of pathological T3 and lymphovascular invasion; however, there were no significant differences in the multivariate analysis. <i>Conclusions</i>: The inflammation-related parameters did not significantly affect the incidence of BCR, at least among patients with PCa who underwent RARP.https://www.mdpi.com/2077-0383/12/24/7732multicenter cohort studyprostate cancerrobot-assisted radical prostatectomyinflammatory-related scoreoncological outcomes |
| spellingShingle | Kazumasa Murase Makoto Kawase Shin Ebara Tomoyuki Tatenuma Takeshi Sasaki Yoshinori Ikehata Akinori Nakayama Masahiro Toide Tatsuaki Yoneda Kazushige Sakaguchi Jun Teishima Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Fumitaka Koga Shinji Urakami Takuya Koie The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) Journal of Clinical Medicine multicenter cohort study prostate cancer robot-assisted radical prostatectomy inflammatory-related score oncological outcomes |
| title | The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) |
| title_full | The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) |
| title_fullStr | The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) |
| title_full_unstemmed | The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) |
| title_short | The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group) |
| title_sort | negative impact of inflammation related parameters in prostate cancer after robot assisted radical prostatectomy a retrospective multicenter cohort study in japan the msug94 group |
| topic | multicenter cohort study prostate cancer robot-assisted radical prostatectomy inflammatory-related score oncological outcomes |
| url | https://www.mdpi.com/2077-0383/12/24/7732 |
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