TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-4...
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MDPI AG
2021-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/11/2301 |
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| author | Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi |
| author_facet | Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi |
| author_sort | Elena Rita Simula |
| collection | DOAJ |
| description | The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-43 in the plasma of ALS patients and healthy controls (HCs). The measured levels of Abs against the different epitopes’ fragments were significantly elevated in ALS patients, both in long-survivor (LS) and newly diagnosed (ND) patients, compared to HCs. We observed a positive correlation between HERV-K and TDP-43 antibodies (Abs) levels, which seemed to strengthen with disease progression, that was not found in HCs. The TDP-43 and HERV-K epitopes identified in this study are highly immunogenic and recognized by the humoral response of ALS patients. Increased circulating levels of Abs directed against specific HERV-K- and TDP-43-derived epitopes could serve as possible biomarkers. |
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| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:59:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-71ad022f1e4b44b28b4fa235c8a5e3052023-11-23T01:58:26ZengMDPI AGViruses1999-49152021-11-011311230110.3390/v13112301TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS PatientsElena Rita Simula0Giannina Arru1Ignazio Roberto Zarbo2Paolo Solla3Leonardo A. Sechi4Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43b, 07100 Sassari, ItalyDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43b, 07100 Sassari, ItalyThe human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-43 in the plasma of ALS patients and healthy controls (HCs). The measured levels of Abs against the different epitopes’ fragments were significantly elevated in ALS patients, both in long-survivor (LS) and newly diagnosed (ND) patients, compared to HCs. We observed a positive correlation between HERV-K and TDP-43 antibodies (Abs) levels, which seemed to strengthen with disease progression, that was not found in HCs. The TDP-43 and HERV-K epitopes identified in this study are highly immunogenic and recognized by the humoral response of ALS patients. Increased circulating levels of Abs directed against specific HERV-K- and TDP-43-derived epitopes could serve as possible biomarkers.https://www.mdpi.com/1999-4915/13/11/2301ALSamyotrophic lateral sclerosisTDP-43HERV-KHML-2 |
| spellingShingle | Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients Viruses ALS amyotrophic lateral sclerosis TDP-43 HERV-K HML-2 |
| title | TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients |
| title_full | TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients |
| title_fullStr | TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients |
| title_full_unstemmed | TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients |
| title_short | TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients |
| title_sort | tdp 43 and herv k envelope specific immunogenic epitopes are recognized in als patients |
| topic | ALS amyotrophic lateral sclerosis TDP-43 HERV-K HML-2 |
| url | https://www.mdpi.com/1999-4915/13/11/2301 |
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