Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells

Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells

Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising therapeutic methods. In this study, we tested the cytotoxicity of novel azulene h...

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Bibliographic Details
Main Authors: Tereza Brogyányi, Robert Kaplánek, Zdeněk Kejík, Božena Hosnedlová, Veronika Antonyová, Nikita Abramenko, Kateřina Veselá, Pavel Martásek, Martin Vokurka, Des R. Richardson, Milan Jakubek
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hydrazone
Cancer
Chelators
NDRG1
HIF-1α
TfR1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222011258

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