Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies
The current health requirements set the direction in pharmacological research, especially as regards diseases that require improvement of existing therapeutic regimens. Such diseases include preeclampsia, which is a hypertensive disorder of pregnancy during which there occurs progressive increasing...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/3/269 |
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| author | Marcin Ożarowski Tomasz M. Karpiński Michał Szulc Karolina Wielgus Radosław Kujawski Hubert Wolski Agnieszka Seremak-Mrozikiewicz |
| author_facet | Marcin Ożarowski Tomasz M. Karpiński Michał Szulc Karolina Wielgus Radosław Kujawski Hubert Wolski Agnieszka Seremak-Mrozikiewicz |
| author_sort | Marcin Ożarowski |
| collection | DOAJ |
| description | The current health requirements set the direction in pharmacological research, especially as regards diseases that require improvement of existing therapeutic regimens. Such diseases include preeclampsia, which is a hypertensive disorder of pregnancy during which there occurs progressive increasing activation of the immune system through elevation of pro-inflammatory cytokines and antiangiogenic factors, which is dangerous for the mother and fetus. A promising field of research for new drugs to treat this disease is the study of natural phenolic compounds of plant origin and herbal extracts, which are complex matrices of chemical compounds with broad biological activities. Many plant substances with anti‑inflammatory and anti‑hypertensive properties are known, but studies in animal models of preeclampsia and clinical trials concerning this disease constitute a new and developing research trend of significant medical importance. The aim of our research review was to identify and analyze the results of already available studies on baicalin, curcumin, epigallocatechin gallate, punicalagin, quercetin, resveratrol, salvianolic acid A (danshensu), silibinin, and vitexin, as well as plant extracts from <i>Brassica oleracea</i> L., <i>Euterpe oleracea</i> Mart., <i>Moringa oleifera</i> Lam., <i>Punica granatum</i> L., <i>Silybum marianum</i> (L.) Gaertner, <i>Thymus schimperi</i> Ronniger, <i>Uncaria rhynchophylla</i> (Miq.) Miq. ex Havil., and <i>Vitis vinifera</i> L., which are potential and promising candidates for further research and for potential new therapies. |
| first_indexed | 2024-03-10T13:11:40Z |
| format | Article |
| id | doaj.art-71b2f1c0ef824e12abdd659c0b67d880 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T13:11:40Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-71b2f1c0ef824e12abdd659c0b67d8802023-11-21T10:41:01ZengMDPI AGPharmaceuticals1424-82472021-03-0114326910.3390/ph14030269Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel TherapiesMarcin Ożarowski0Tomasz M. Karpiński1Michał Szulc2Karolina Wielgus3Radosław Kujawski4Hubert Wolski5Agnieszka Seremak-Mrozikiewicz6Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznań, PolandChair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, PolandDepartment of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, PolandDepartment of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznań, PolandDepartment of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, PolandDivision of Gynecology and Obstetrics, Podhale Multidisciplinary Hospital, 34-400 Nowy Targ, PolandDivision of Perinatology and Women’s Diseases, Poznań University of Medical Sciences, Polna 33, 60-535 Poznań, PolandThe current health requirements set the direction in pharmacological research, especially as regards diseases that require improvement of existing therapeutic regimens. Such diseases include preeclampsia, which is a hypertensive disorder of pregnancy during which there occurs progressive increasing activation of the immune system through elevation of pro-inflammatory cytokines and antiangiogenic factors, which is dangerous for the mother and fetus. A promising field of research for new drugs to treat this disease is the study of natural phenolic compounds of plant origin and herbal extracts, which are complex matrices of chemical compounds with broad biological activities. Many plant substances with anti‑inflammatory and anti‑hypertensive properties are known, but studies in animal models of preeclampsia and clinical trials concerning this disease constitute a new and developing research trend of significant medical importance. The aim of our research review was to identify and analyze the results of already available studies on baicalin, curcumin, epigallocatechin gallate, punicalagin, quercetin, resveratrol, salvianolic acid A (danshensu), silibinin, and vitexin, as well as plant extracts from <i>Brassica oleracea</i> L., <i>Euterpe oleracea</i> Mart., <i>Moringa oleifera</i> Lam., <i>Punica granatum</i> L., <i>Silybum marianum</i> (L.) Gaertner, <i>Thymus schimperi</i> Ronniger, <i>Uncaria rhynchophylla</i> (Miq.) Miq. ex Havil., and <i>Vitis vinifera</i> L., which are potential and promising candidates for further research and for potential new therapies.https://www.mdpi.com/1424-8247/14/3/269phenolic compoundsplant extractsin vivo models of preeclampsiaclinical trials |
| spellingShingle | Marcin Ożarowski Tomasz M. Karpiński Michał Szulc Karolina Wielgus Radosław Kujawski Hubert Wolski Agnieszka Seremak-Mrozikiewicz Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies Pharmaceuticals phenolic compounds plant extracts in vivo models of preeclampsia clinical trials |
| title | Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies |
| title_full | Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies |
| title_fullStr | Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies |
| title_full_unstemmed | Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies |
| title_short | Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies |
| title_sort | plant phenolics and extracts in animal models of preeclampsia and clinical trials review of perspectives for novel therapies |
| topic | phenolic compounds plant extracts in vivo models of preeclampsia clinical trials |
| url | https://www.mdpi.com/1424-8247/14/3/269 |
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