Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials
Background: Male gender has been consistently shown to be a risk factor for a greater number of arrhythmic events in patients with Brugada Syndrome (BrS). However, there have been no large-scale comprehensive pooled analyses to statistically and systematically verify this association. Therefore, we...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01127/full |
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| author | Mengchen Yuan Mengchen Yuan Chao Tian Chao Tian Xinye Li Xinyu Yang Xinyu Yang Xiaofeng Wang Yihan Yang Yihan Yang Nian Liu Kengo F. Kusano Hector Barajas-Martinez Dan Hu Dan Hu Hongcai Shang Yonghong Gao Yanwei Xing |
| author_facet | Mengchen Yuan Mengchen Yuan Chao Tian Chao Tian Xinye Li Xinyu Yang Xinyu Yang Xiaofeng Wang Yihan Yang Yihan Yang Nian Liu Kengo F. Kusano Hector Barajas-Martinez Dan Hu Dan Hu Hongcai Shang Yonghong Gao Yanwei Xing |
| author_sort | Mengchen Yuan |
| collection | DOAJ |
| description | Background: Male gender has been consistently shown to be a risk factor for a greater number of arrhythmic events in patients with Brugada Syndrome (BrS). However, there have been no large-scale comprehensive pooled analyses to statistically and systematically verify this association. Therefore, we conducted a pooled analysis on gender differences in prognosis and risk stratification of BrS with a largest sample capacity at present.Methods: We searched PubMed, Embase, Medline, Cochrane Library databases, Chinese National Knowledge Infrastructure, and Wanfang Data for relevant studies published from 2002 to 2017. The prognosis and risk stratification of BrS and risk factors were then investigated and evaluated according to gender.Results: Twenty-four eligible studies involving 4,140 patients were included in the analysis. Male patients (78.1%) had a higher risk of arrhythmic events than female patients (95% confidence interval: 1.46–2.91, P < 0.0001). Among the male population, there were statistical differences between symptomatic patients and asymptomatic patients (95% CI: 2.63–7.86, P < 0.00001), but in the female population, no statistical differences were found. In the female subgroup, electrophysiological study (EPS) positive patients had a tendency toward a higher risk of arrhythmic events than EPS-negative patients (95% CI: 0.93–29.77, P = 0.06).Conclusions: Male patients are at a higher risk of arrhythmic events than female patients. Within the male population, symptomatic patients have a significantly higher risk profile compared to asymptomatic patients, but no such differences are evident within the female population. Consequently, in the female population, the risk of asymptomatic patterns cannot be underestimated. |
| first_indexed | 2024-12-23T20:05:05Z |
| format | Article |
| id | doaj.art-71b46e43be524311b42fc9b45b0d0676 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T20:05:05Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-71b46e43be524311b42fc9b45b0d06762022-12-21T17:32:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-08-01910.3389/fphys.2018.01127398412Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical TrialsMengchen Yuan0Mengchen Yuan1Chao Tian2Chao Tian3Xinye Li4Xinyu Yang5Xinyu Yang6Xiaofeng Wang7Yihan Yang8Yihan Yang9Nian Liu10Kengo F. Kusano11Hector Barajas-Martinez12Dan Hu13Dan Hu14Hongcai Shang15Yonghong Gao16Yanwei Xing17Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Cardiology, Beijing An Zhen Hospital of the Capital University of Medical Sciences, Beijing, ChinaDivision of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanMasonic Medical Research Laboratory, Utica, NY, United StatesMasonic Medical Research Laboratory, Utica, NY, United StatesHubei Key Laboratory of Cardiology, Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, ChinaBackground: Male gender has been consistently shown to be a risk factor for a greater number of arrhythmic events in patients with Brugada Syndrome (BrS). However, there have been no large-scale comprehensive pooled analyses to statistically and systematically verify this association. Therefore, we conducted a pooled analysis on gender differences in prognosis and risk stratification of BrS with a largest sample capacity at present.Methods: We searched PubMed, Embase, Medline, Cochrane Library databases, Chinese National Knowledge Infrastructure, and Wanfang Data for relevant studies published from 2002 to 2017. The prognosis and risk stratification of BrS and risk factors were then investigated and evaluated according to gender.Results: Twenty-four eligible studies involving 4,140 patients were included in the analysis. Male patients (78.1%) had a higher risk of arrhythmic events than female patients (95% confidence interval: 1.46–2.91, P < 0.0001). Among the male population, there were statistical differences between symptomatic patients and asymptomatic patients (95% CI: 2.63–7.86, P < 0.00001), but in the female population, no statistical differences were found. In the female subgroup, electrophysiological study (EPS) positive patients had a tendency toward a higher risk of arrhythmic events than EPS-negative patients (95% CI: 0.93–29.77, P = 0.06).Conclusions: Male patients are at a higher risk of arrhythmic events than female patients. Within the male population, symptomatic patients have a significantly higher risk profile compared to asymptomatic patients, but no such differences are evident within the female population. Consequently, in the female population, the risk of asymptomatic patterns cannot be underestimated.https://www.frontiersin.org/article/10.3389/fphys.2018.01127/fullBrugada syndromegender differenceelectrophysiological studyprognosisrisk stratification |
| spellingShingle | Mengchen Yuan Mengchen Yuan Chao Tian Chao Tian Xinye Li Xinyu Yang Xinyu Yang Xiaofeng Wang Yihan Yang Yihan Yang Nian Liu Kengo F. Kusano Hector Barajas-Martinez Dan Hu Dan Hu Hongcai Shang Yonghong Gao Yanwei Xing Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials Frontiers in Physiology Brugada syndrome gender difference electrophysiological study prognosis risk stratification |
| title | Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials |
| title_full | Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials |
| title_fullStr | Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials |
| title_full_unstemmed | Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials |
| title_short | Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials |
| title_sort | gender differences in prognosis and risk stratification of brugada syndrome a pooled analysis of 4 140 patients from 24 clinical trials |
| topic | Brugada syndrome gender difference electrophysiological study prognosis risk stratification |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01127/full |
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