Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, iden...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7619 |
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| author | James Greenan-Barrett Georgia Doolan Devina Shah Simrun Virdee George A. Robinson Varvara Choida Nataliya Gak Nina de Gruijter Elizabeth Rosser Muthana Al-Obaidi Maria Leandro Michael S. Zandi Ruth J. Pepper Alan Salama Elizabeth C. Jury Coziana Ciurtin |
| author_facet | James Greenan-Barrett Georgia Doolan Devina Shah Simrun Virdee George A. Robinson Varvara Choida Nataliya Gak Nina de Gruijter Elizabeth Rosser Muthana Al-Obaidi Maria Leandro Michael S. Zandi Ruth J. Pepper Alan Salama Elizabeth C. Jury Coziana Ciurtin |
| author_sort | James Greenan-Barrett |
| collection | DOAJ |
| description | Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications. |
| first_indexed | 2024-03-10T09:36:19Z |
| format | Article |
| id | doaj.art-71b48ce4195847ff9924718486a695c7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:19Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71b48ce4195847ff9924718486a695c72023-11-22T04:01:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214761910.3390/ijms22147619Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus ErythematosusJames Greenan-Barrett0Georgia Doolan1Devina Shah2Simrun Virdee3George A. Robinson4Varvara Choida5Nataliya Gak6Nina de Gruijter7Elizabeth Rosser8Muthana Al-Obaidi9Maria Leandro10Michael S. Zandi11Ruth J. Pepper12Alan Salama13Elizabeth C. Jury14Coziana Ciurtin15Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKDepartment of Ophthalmology, Royal Free Hospital, London NW3 2QG, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKDepartment of Rheumatology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKDepartment of Paediatric Rheumatology, Great Ormond Street Hospital, London WC1N 3JH, UKDepartment of Rheumatology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UKDepartment of Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UKDepartment of Renal Medicine, Royal Free Hospital, University College London, London NW3 2QG, UKDepartment of Renal Medicine, Royal Free Hospital, University College London, London NW3 2QG, UKCentre for Rheumatology, Division of Medicine, University College London, London WC1E 6DH, UKCentre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UKJuvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.https://www.mdpi.com/1422-0067/22/14/7619juvenile systemic lupus erythematosusorgan-specific biomarkersrenal biomarkerscardiovascular biomarkershaematological biomarkersneurological biomarkers |
| spellingShingle | James Greenan-Barrett Georgia Doolan Devina Shah Simrun Virdee George A. Robinson Varvara Choida Nataliya Gak Nina de Gruijter Elizabeth Rosser Muthana Al-Obaidi Maria Leandro Michael S. Zandi Ruth J. Pepper Alan Salama Elizabeth C. Jury Coziana Ciurtin Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus International Journal of Molecular Sciences juvenile systemic lupus erythematosus organ-specific biomarkers renal biomarkers cardiovascular biomarkers haematological biomarkers neurological biomarkers |
| title | Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus |
| title_full | Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus |
| title_fullStr | Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus |
| title_full_unstemmed | Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus |
| title_short | Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus |
| title_sort | biomarkers associated with organ specific involvement in juvenile systemic lupus erythematosus |
| topic | juvenile systemic lupus erythematosus organ-specific biomarkers renal biomarkers cardiovascular biomarkers haematological biomarkers neurological biomarkers |
| url | https://www.mdpi.com/1422-0067/22/14/7619 |
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