Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin
Active substances, effective in the reduction in or delay of skin changes caused by aging occurring in natural compounds, are desirable. Taxifolin (TXF), a flavonoid of strong antioxidant activity found in the plant <i>Stizolophus balsamita</i> (<i>S. balsamita</i>), has been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/10/1625 |
| _version_ | 1797515432564883456 |
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| author | Iwona Micek Joanna Nawrot Agnieszka Seraszek-Jaros Dorota Jenerowicz Grzegorz Schroeder Tomasz Spiżewski Adela Suchan Mariola Pawlaczyk Justyna Gornowicz-Porowska |
| author_facet | Iwona Micek Joanna Nawrot Agnieszka Seraszek-Jaros Dorota Jenerowicz Grzegorz Schroeder Tomasz Spiżewski Adela Suchan Mariola Pawlaczyk Justyna Gornowicz-Porowska |
| author_sort | Iwona Micek |
| collection | DOAJ |
| description | Active substances, effective in the reduction in or delay of skin changes caused by aging occurring in natural compounds, are desirable. Taxifolin (TXF), a flavonoid of strong antioxidant activity found in the plant <i>Stizolophus balsamita</i> (<i>S. balsamita</i>), has been tested for its biological effects on adult human skin. The aim of the study was to investigate the effects of two creams: 3% <i>S. balsamita</i> extract and 3% TXF on the function of adult skin. In total, 97 Caucasian women with clinical signs of skin aging were investigated. The biophysical and biomechanical skin parameters were measured before and after applying the creams, using Colorimeter CL400, Mexameter MX16, Skin-pH-Meter PH900, Skin-Thermometer ST 500, Glossymeter GL200, and Cutiscan SC100. Patch tests were performed with the investigated products to assess their potential irritant properties. The percutaneous penetration of creams was examined with the use of electrospray ionization mass spectrometry (ESI-MS) and confocal Raman spectroscopy. The 3% <i>S. balsamita</i> extract cream reduced hyperpigmentation, erythema, and elevated pH. All the tested preparations were proven to be nonirritant. A higher penetration rate was revealed for the 3% TXF cream than for the 3% <i>S. balsamita</i> extract cream. A total of 3% TXF cream improved skin viscoelasticity. The obtained results suggested that <i>S. balsamita</i> extract and TXF may be considered as ingredients of skincare products for adults. |
| first_indexed | 2024-03-10T06:45:24Z |
| format | Article |
| id | doaj.art-71b559bd61f1450bb5742fcbaf0dedac |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T06:45:24Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-71b559bd61f1450bb5742fcbaf0dedac2023-11-22T17:16:55ZengMDPI AGAntioxidants2076-39212021-10-011010162510.3390/antiox10101625Taxifolin as a Promising Ingredient of Cosmetics for Adult SkinIwona Micek0Joanna Nawrot1Agnieszka Seraszek-Jaros2Dorota Jenerowicz3Grzegorz Schroeder4Tomasz Spiżewski5Adela Suchan6Mariola Pawlaczyk7Justyna Gornowicz-Porowska8Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznan, PolandDepartment and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznan, PolandDepartment of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, 4 Rokietnicka Street, 60-806 Poznan, PolandDepartment of Dermatology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-356 Poznan, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznańskiego 8 Street, 61-614 Poznan, PolandDepartment of Vegetable Crops, Poznan University of Life Sciences, Dąbrowskiego 159 Street, 60-594 Poznan, PolandAVA Cosmetic Laboratory, Całowanie 103B, 05-480 Karczew, PolandDepartment and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznan, PolandDepartment and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznan, PolandActive substances, effective in the reduction in or delay of skin changes caused by aging occurring in natural compounds, are desirable. Taxifolin (TXF), a flavonoid of strong antioxidant activity found in the plant <i>Stizolophus balsamita</i> (<i>S. balsamita</i>), has been tested for its biological effects on adult human skin. The aim of the study was to investigate the effects of two creams: 3% <i>S. balsamita</i> extract and 3% TXF on the function of adult skin. In total, 97 Caucasian women with clinical signs of skin aging were investigated. The biophysical and biomechanical skin parameters were measured before and after applying the creams, using Colorimeter CL400, Mexameter MX16, Skin-pH-Meter PH900, Skin-Thermometer ST 500, Glossymeter GL200, and Cutiscan SC100. Patch tests were performed with the investigated products to assess their potential irritant properties. The percutaneous penetration of creams was examined with the use of electrospray ionization mass spectrometry (ESI-MS) and confocal Raman spectroscopy. The 3% <i>S. balsamita</i> extract cream reduced hyperpigmentation, erythema, and elevated pH. All the tested preparations were proven to be nonirritant. A higher penetration rate was revealed for the 3% TXF cream than for the 3% <i>S. balsamita</i> extract cream. A total of 3% TXF cream improved skin viscoelasticity. The obtained results suggested that <i>S. balsamita</i> extract and TXF may be considered as ingredients of skincare products for adults.https://www.mdpi.com/2076-3921/10/10/1625taxifolin<i>Stizolophus balsamita</i>natural antioxidantpermeabilityskin aging |
| spellingShingle | Iwona Micek Joanna Nawrot Agnieszka Seraszek-Jaros Dorota Jenerowicz Grzegorz Schroeder Tomasz Spiżewski Adela Suchan Mariola Pawlaczyk Justyna Gornowicz-Porowska Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin Antioxidants taxifolin <i>Stizolophus balsamita</i> natural antioxidant permeability skin aging |
| title | Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin |
| title_full | Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin |
| title_fullStr | Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin |
| title_full_unstemmed | Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin |
| title_short | Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin |
| title_sort | taxifolin as a promising ingredient of cosmetics for adult skin |
| topic | taxifolin <i>Stizolophus balsamita</i> natural antioxidant permeability skin aging |
| url | https://www.mdpi.com/2076-3921/10/10/1625 |
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