Characterization, in Vivo and in Vitro Evaluation of Solid Dispersion of Curcumin Containing d-α-Tocopheryl Polyethylene Glycol 1000 Succinate and Mannitol

Characterization, in Vivo and in Vitro Evaluation of Solid Dispersion of Curcumin Containing d-α-Tocopheryl Polyethylene Glycol 1000 Succinate and Mannitol

The aim of this study was to prepare a solid dispersion formulation of curcumin to enhance its solubility, dissolution rate, and oral bioavailability. The formulation was prepared with d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and mannitol using solvent evaporation and freeze-drying m...

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Bibliographic Details
Main Authors: Im-Sook Song, Jin-Sun Cha, Min-Koo Choi
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
curcumin
TPGS
solid dispersion
dissolution
oral bioavailability
Online Access:http://www.mdpi.com/1420-3049/21/10/1386

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