Atypical cell cycle profile of mouse embryonic stem cell is regulated by classic oncogenic and tumor suppressive genes in vitro

Atypical cell cycle profile of mouse embryonic stem cell is regulated by classic oncogenic and tumor suppressive genes in vitro

Embryonic stem cells (ESCs) exhibit an unusual cell cycle profile containing a short G1 phase. Whether this feature is required to maintain pluripotency is a matter of debate. Here, we report that the short G1 phase is a consequence of MEK1/2 kinase-mediated promotion of G1/S transition, but not nec...

Full description

Bibliographic Details
Main Authors: Jinfeng Jiang, Tong Qiu, Chao Yang, Yuan Yuan, Ling Qin, Peixuan Zhang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Cell cycle
Embryonic stem cell
P53
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022032674

Similar Items

Similar Items