| Summary: | Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is <i>Vitex agnus-castus</i> L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. In this perspective article, the in vitro and in vivo therapeutic properties of <i>V.</i> <i>agnus-castus</i> L. have been analyzed and reviewed with a special focus on its health-promoting effects and potential nutraceutical applications.
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