A novel TBX5 mutation predisposes to familial cardiac septal defects and atrial fibrillation as well as bicuspid aortic valve

A novel TBX5 mutation predisposes to familial cardiac septal defects and atrial fibrillation as well as bicuspid aortic valve

Abstract TBX5 has been linked to Holt-Oram syndrome, with congenital heart defect (CHD) and atrial fibrillation (AF) being two major cardiac phenotypes. However, the prevalence of a TBX5 variation in patients with CHD and AF remains obscure. In this research, by sequencing analysis of TBX5 in 178 in...

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Bibliographic Details
Main Authors: Wei-Feng Jiang, Ying-Jia Xu, Cui-Mei Zhao, Xin-Hua Wang, Xing-Biao Qiu, Xu Liu, Shao-Hui Wu, Yi-Qing Yang
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2020-11-01
Series:Genetics and Molecular Biology
Subjects:
Congenital heart disease
atrial fibrillation
bicuspid aortic valve
molecular genetics
TBX5
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000600104&tlng=en

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