Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.810887/full |
| _version_ | 1828133178351550464 |
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| author | Alejandro Urrea-Quezada Ruben Balmaceda-Baca Adriana Garibay Jesús Hernández Olivia Valenzuela |
| author_facet | Alejandro Urrea-Quezada Ruben Balmaceda-Baca Adriana Garibay Jesús Hernández Olivia Valenzuela |
| author_sort | Alejandro Urrea-Quezada |
| collection | DOAJ |
| description | Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates. |
| first_indexed | 2024-04-11T17:15:52Z |
| format | Article |
| id | doaj.art-71bf3a501dcb4e868c1ab1a697bc0f76 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T17:15:52Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-71bf3a501dcb4e868c1ab1a697bc0f762022-12-22T04:12:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-01-011110.3389/fcimb.2021.810887810887Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvumAlejandro Urrea-Quezada0Ruben Balmaceda-Baca1Adriana Garibay2Jesús Hernández3Olivia Valenzuela4Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, MexicoLaboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo A. C., Hermosillo, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, MexicoCryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.https://www.frontiersin.org/articles/10.3389/fcimb.2021.810887/fullhuman cryptosporidiosisemerging parasiteshumoral responsesynthetic peptidesIgG |
| spellingShingle | Alejandro Urrea-Quezada Ruben Balmaceda-Baca Adriana Garibay Jesús Hernández Olivia Valenzuela Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum Frontiers in Cellular and Infection Microbiology human cryptosporidiosis emerging parasites humoral response synthetic peptides IgG |
| title | Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum |
| title_full | Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum |
| title_fullStr | Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum |
| title_full_unstemmed | Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum |
| title_short | Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum |
| title_sort | serum igg responses to gp15 and gp40 protein derived synthetic peptides from cryptosporidium parvum |
| topic | human cryptosporidiosis emerging parasites humoral response synthetic peptides IgG |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.810887/full |
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