Understanding the role of neutrophils in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to life-threatening ARDS. Neutrophil counts are positively correlated with disease severity in ARDS. Neutrophil activa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417020301499 |
| _version_ | 1817990852381769728 |
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| author | Shun-Chin Yang Yung-Fong Tsai Yen-Lin Pan Tsong-Long Hwang |
| author_facet | Shun-Chin Yang Yung-Fong Tsai Yen-Lin Pan Tsong-Long Hwang |
| author_sort | Shun-Chin Yang |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to life-threatening ARDS. Neutrophil counts are positively correlated with disease severity in ARDS. Neutrophil activation not only plays a significant role in immune defense against infections, but also causes tissue damage and leads to inflammatory diseases. Activated neutrophils rapidly migrate to inflamed lung tissue, releasing toxic granular contents and generating neutrophil extracellular traps. In the last few decades, it has become apparent that neutrophils occupy a central role in ARDS pathology. In this review, we summarize the neutrophil inflammatory responses and their relationships to ARDS. According to the current literature, understanding the function of neutrophils may be helpful in the treatment of ARDS. |
| first_indexed | 2024-04-14T01:05:27Z |
| format | Article |
| id | doaj.art-71bf483c9b2e440b8d79274ce6093ffc |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-14T01:05:27Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-71bf483c9b2e440b8d79274ce6093ffc2022-12-22T02:21:16ZengElsevierBiomedical Journal2319-41702021-08-01444439446Understanding the role of neutrophils in acute respiratory distress syndromeShun-Chin Yang0Yung-Fong Tsai1Yen-Lin Pan2Tsong-Long Hwang3Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pharmacy, Cheng Hsin General Hospital, Taipei, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan; Corresponding author. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259, Wenhua 1st Rd., Gueishan, Taoyuan 333, Taiwan.Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to life-threatening ARDS. Neutrophil counts are positively correlated with disease severity in ARDS. Neutrophil activation not only plays a significant role in immune defense against infections, but also causes tissue damage and leads to inflammatory diseases. Activated neutrophils rapidly migrate to inflamed lung tissue, releasing toxic granular contents and generating neutrophil extracellular traps. In the last few decades, it has become apparent that neutrophils occupy a central role in ARDS pathology. In this review, we summarize the neutrophil inflammatory responses and their relationships to ARDS. According to the current literature, understanding the function of neutrophils may be helpful in the treatment of ARDS.http://www.sciencedirect.com/science/article/pii/S2319417020301499ARDSNeutrophilInflammation |
| spellingShingle | Shun-Chin Yang Yung-Fong Tsai Yen-Lin Pan Tsong-Long Hwang Understanding the role of neutrophils in acute respiratory distress syndrome Biomedical Journal ARDS Neutrophil Inflammation |
| title | Understanding the role of neutrophils in acute respiratory distress syndrome |
| title_full | Understanding the role of neutrophils in acute respiratory distress syndrome |
| title_fullStr | Understanding the role of neutrophils in acute respiratory distress syndrome |
| title_full_unstemmed | Understanding the role of neutrophils in acute respiratory distress syndrome |
| title_short | Understanding the role of neutrophils in acute respiratory distress syndrome |
| title_sort | understanding the role of neutrophils in acute respiratory distress syndrome |
| topic | ARDS Neutrophil Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2319417020301499 |
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