Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis
Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Init...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/7/2691 |
| _version_ | 1797607573393768448 |
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| author | Greg Gilles Arjun Vohra Dagoberto Robles Mihra S. Taljanovic Erin L. Ashbeck Chelsea Caruso Jeffrey Duryea Edward J. Bedrick Ali Guermazi C. Kent Kwoh |
| author_facet | Greg Gilles Arjun Vohra Dagoberto Robles Mihra S. Taljanovic Erin L. Ashbeck Chelsea Caruso Jeffrey Duryea Edward J. Bedrick Ali Guermazi C. Kent Kwoh |
| author_sort | Greg Gilles |
| collection | DOAJ |
| description | Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren–Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans blinded to prior assessments. The estimated intraclass correlation coefficient (ICC) for intra-reader reliability of the single-slice ES method in the KL 2–3 sample was 0.96 (95% CI: 0.93, 0.97), and for inter-reader reliability, the ICC was 0.90 (95% CI: 0.87, 0.95). The intra-reader mean absolute difference (MAD) was 35 mm<sup>3</sup> (95% CI: 28, 44), and the inter-reader MAD was 61 mm<sup>3</sup> (95% CI: 48, 76). Our single-slice quantitative knee ES measurement offers a reliable, valid, and efficient surrogate for multi-slice quantitative and semi-quantitative assessment. |
| first_indexed | 2024-03-11T05:32:52Z |
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| id | doaj.art-71c0c28688a042fc8edef48b4b154ce5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:32:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-71c0c28688a042fc8edef48b4b154ce52023-11-17T17:00:37ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01127269110.3390/jcm12072691Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with OsteoarthritisGreg Gilles0Arjun Vohra1Dagoberto Robles2Mihra S. Taljanovic3Erin L. Ashbeck4Chelsea Caruso5Jeffrey Duryea6Edward J. Bedrick7Ali Guermazi8C. Kent Kwoh9University of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USADepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USAVA Boston Healthcare System, West Roxbury, Boston, MA 02132, USAUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USAEffusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren–Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans blinded to prior assessments. The estimated intraclass correlation coefficient (ICC) for intra-reader reliability of the single-slice ES method in the KL 2–3 sample was 0.96 (95% CI: 0.93, 0.97), and for inter-reader reliability, the ICC was 0.90 (95% CI: 0.87, 0.95). The intra-reader mean absolute difference (MAD) was 35 mm<sup>3</sup> (95% CI: 28, 44), and the inter-reader MAD was 61 mm<sup>3</sup> (95% CI: 48, 76). Our single-slice quantitative knee ES measurement offers a reliable, valid, and efficient surrogate for multi-slice quantitative and semi-quantitative assessment.https://www.mdpi.com/2077-0383/12/7/2691MRIosteoarthritisquantitative imagingkneebiomarkerseffusion |
| spellingShingle | Greg Gilles Arjun Vohra Dagoberto Robles Mihra S. Taljanovic Erin L. Ashbeck Chelsea Caruso Jeffrey Duryea Edward J. Bedrick Ali Guermazi C. Kent Kwoh Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis Journal of Clinical Medicine MRI osteoarthritis quantitative imaging knee biomarkers effusion |
| title | Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis |
| title_full | Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis |
| title_fullStr | Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis |
| title_full_unstemmed | Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis |
| title_short | Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis |
| title_sort | reliability and validity of single axial slice vs multiple slice quantitative measurement of the volume of effusion synovitis on 3t knee mri in knees with osteoarthritis |
| topic | MRI osteoarthritis quantitative imaging knee biomarkers effusion |
| url | https://www.mdpi.com/2077-0383/12/7/2691 |
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