Amino Acid-Metabolizing Enzymes in Advanced High-Grade Serous Ovarian Cancer Patients: Value of Ascites as Biomarker Source and Role for IL4I1 and IDO1

Amino Acid-Metabolizing Enzymes in Advanced High-Grade Serous Ovarian Cancer Patients: Value of Ascites as Biomarker Source and Role for IL4I1 and IDO1

The molecular mechanisms contributing to immune suppression in ovarian cancer are not well understood, hampering the successful application of immunotherapy. Amino acid-metabolizing enzymes are known to contribute to the immune-hostile environment of various tumors through depletion of amino acids a...

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Bibliographic Details
Main Authors: Yvonne Grobben, Judith E. den Ouden, Cristina Aguado, Anne M. van Altena, Aletta D. Kraneveld, Guido J. R. Zaman
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
ovarian cancer
immunotherapy
immunosuppression
liquid biopsy
ascites
metabolomics
Online Access:https://www.mdpi.com/2072-6694/15/3/893

Internet

https://www.mdpi.com/2072-6694/15/3/893

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