Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training
Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and o...
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2023-05-01
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| Series: | Medical Laboratory Journal |
| Subjects: | |
| Online Access: | http://mlj.goums.ac.ir/article-1-1544-en.pdf |
| _version_ | 1797301331582517248 |
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| author | faranak Balaghi Inaloo Roya Askari Amir hossein Haghighi Kaveh kashani Paul Friedemann |
| author_facet | faranak Balaghi Inaloo Roya Askari Amir hossein Haghighi Kaveh kashani Paul Friedemann |
| author_sort | faranak Balaghi Inaloo |
| collection | DOAJ |
| description | Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training.
Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention.
Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group.
Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels. |
| first_indexed | 2024-03-07T23:19:59Z |
| format | Article |
| id | doaj.art-71c0f143ecdd4fada12645574f51b539 |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-03-07T23:19:59Z |
| publishDate | 2023-05-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-71c0f143ecdd4fada12645574f51b5392024-02-21T07:02:21ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492023-05-011735562Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Trainingfaranak Balaghi Inaloo0Roya Askari1Amir hossein Haghighi2Kaveh kashani3Paul Friedemann4 Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran Neurologist, Fars Province, Fasa, Iran Neurologist and Scientific Director of the Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, Germany Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training. Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention. Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group. Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.http://mlj.goums.ac.ir/article-1-1544-en.pdfexercise movement techniquesneurofilament proteinvitamin dfatiguemultiple sclerosis |
| spellingShingle | faranak Balaghi Inaloo Roya Askari Amir hossein Haghighi Kaveh kashani Paul Friedemann Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training Medical Laboratory Journal exercise movement techniques neurofilament protein vitamin d fatigue multiple sclerosis |
| title | Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training |
| title_full | Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training |
| title_fullStr | Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training |
| title_full_unstemmed | Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training |
| title_short | Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training |
| title_sort | decreased serum neurofilament light chain and fatigue severity in patients with multiple sclerosis after home based and outdoor pilates training |
| topic | exercise movement techniques neurofilament protein vitamin d fatigue multiple sclerosis |
| url | http://mlj.goums.ac.ir/article-1-1544-en.pdf |
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