Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India
Background: The world witnessed the emergence of a global pandemic. Individuals with chronic illnesses like chronic kidney disease (CKD), already known to be immunologically compromised, have the potential to develop a scenario of an acute-on-chronic condition on coronavirus disease 2019 (COVID-19)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Current Medicine Research and Practice |
| Subjects: | |
| Online Access: | http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2023;volume=13;issue=4;spage=156;epage=162;aulast=Khurana |
| _version_ | 1827783332951228416 |
|---|---|
| author | Vatsala Khurana Binita Goswami Sunita Aggarwal Smita Kaushik |
| author_facet | Vatsala Khurana Binita Goswami Sunita Aggarwal Smita Kaushik |
| author_sort | Vatsala Khurana |
| collection | DOAJ |
| description | Background: The world witnessed the emergence of a global pandemic. Individuals with chronic illnesses like chronic kidney disease (CKD), already known to be immunologically compromised, have the potential to develop a scenario of an acute-on-chronic condition on coronavirus disease 2019 (COVID-19) contraction. Measurement of serum inflammatory biomarkers like interleukin (IL-6), high-sensitivity C-reactive protein (hsCRP) and ferritin may foresee the prognosis despite the pre-existing low-grade inflammation in these patients.
Aims: To determine the utility of serum IL-6, hsCRP and Ferritin levels to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19.
Materials and Methods: A cross-sectional study was performed on 100 adult known cases of stage 5 of CKD, recently diagnosed as COVID-19 positive by real-time reverse transcription-polymerase chain reaction. The study population was divided into two groups according to COVID-19 severity: A non-severe and a severe group based on guidelines given in the Clinical Management Protocol: COVID-19. Their clinical and laboratory data obtained on the day of admission were analysed.
Results: The severe group (n = 17) had 65% of males and 35% of females. A significant difference was found with respect to the age, body mass index and serum IL-6, hsCRP and ferritin levels between the two groups (P < 0.05). Among the three inflammatory biomarkers, hsCRP was found to have the maximum potential to categorise COVID-19 as severe or non-severe disease.
Conclusion: Similar to patients with uncomplicated COVID-19 disease, higher serum levels of inflammatory biomarkers – IL-6, hsCRP and ferritin are seen in patients of CKD with severe COVID-19 illness in comparison to those with non-severe COVID-19, despite having a pre-existing background of low-grade chronic inflammation. The serum levels of IL-6, hsCRP and ferritin can be utilised to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19. |
| first_indexed | 2024-03-11T15:46:05Z |
| format | Article |
| id | doaj.art-71c125fc59794e9bb657b5916dc3f6e5 |
| institution | Directory Open Access Journal |
| issn | 2352-0817 2352-0825 |
| language | English |
| last_indexed | 2024-03-11T15:46:05Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Current Medicine Research and Practice |
| spelling | doaj.art-71c125fc59794e9bb657b5916dc3f6e52023-10-26T06:18:41ZengWolters Kluwer Medknow PublicationsCurrent Medicine Research and Practice2352-08172352-08252023-01-0113415616210.4103/cmrp.cmrp_113_22Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North IndiaVatsala KhuranaBinita GoswamiSunita AggarwalSmita KaushikBackground: The world witnessed the emergence of a global pandemic. Individuals with chronic illnesses like chronic kidney disease (CKD), already known to be immunologically compromised, have the potential to develop a scenario of an acute-on-chronic condition on coronavirus disease 2019 (COVID-19) contraction. Measurement of serum inflammatory biomarkers like interleukin (IL-6), high-sensitivity C-reactive protein (hsCRP) and ferritin may foresee the prognosis despite the pre-existing low-grade inflammation in these patients. Aims: To determine the utility of serum IL-6, hsCRP and Ferritin levels to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19. Materials and Methods: A cross-sectional study was performed on 100 adult known cases of stage 5 of CKD, recently diagnosed as COVID-19 positive by real-time reverse transcription-polymerase chain reaction. The study population was divided into two groups according to COVID-19 severity: A non-severe and a severe group based on guidelines given in the Clinical Management Protocol: COVID-19. Their clinical and laboratory data obtained on the day of admission were analysed. Results: The severe group (n = 17) had 65% of males and 35% of females. A significant difference was found with respect to the age, body mass index and serum IL-6, hsCRP and ferritin levels between the two groups (P < 0.05). Among the three inflammatory biomarkers, hsCRP was found to have the maximum potential to categorise COVID-19 as severe or non-severe disease. Conclusion: Similar to patients with uncomplicated COVID-19 disease, higher serum levels of inflammatory biomarkers – IL-6, hsCRP and ferritin are seen in patients of CKD with severe COVID-19 illness in comparison to those with non-severe COVID-19, despite having a pre-existing background of low-grade chronic inflammation. The serum levels of IL-6, hsCRP and ferritin can be utilised to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19.http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2023;volume=13;issue=4;spage=156;epage=162;aulast=Khuranachronic kidney diseasecoronavirus disease 2019inflammatory profilesevere disease |
| spellingShingle | Vatsala Khurana Binita Goswami Sunita Aggarwal Smita Kaushik Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India Current Medicine Research and Practice chronic kidney disease coronavirus disease 2019 inflammatory profile severe disease |
| title | Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India |
| title_full | Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India |
| title_fullStr | Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India |
| title_full_unstemmed | Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India |
| title_short | Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India |
| title_sort | implications of inflammatory markers for disease management in patients with chronic kidney disease and covid 19 infection a cross sectional study from north india |
| topic | chronic kidney disease coronavirus disease 2019 inflammatory profile severe disease |
| url | http://www.cmrpjournal.org/article.asp?issn=2352-0817;year=2023;volume=13;issue=4;spage=156;epage=162;aulast=Khurana |
| work_keys_str_mv | AT vatsalakhurana implicationsofinflammatorymarkersfordiseasemanagementinpatientswithchronickidneydiseaseandcovid19infectionacrosssectionalstudyfromnorthindia AT binitagoswami implicationsofinflammatorymarkersfordiseasemanagementinpatientswithchronickidneydiseaseandcovid19infectionacrosssectionalstudyfromnorthindia AT sunitaaggarwal implicationsofinflammatorymarkersfordiseasemanagementinpatientswithchronickidneydiseaseandcovid19infectionacrosssectionalstudyfromnorthindia AT smitakaushik implicationsofinflammatorymarkersfordiseasemanagementinpatientswithchronickidneydiseaseandcovid19infectionacrosssectionalstudyfromnorthindia |