RAFT-Based Polymers for Click Reactions
The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/3/570 |
| _version_ | 1797485218237513728 |
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| author | Elena V. Chernikova Yaroslav V. Kudryavtsev |
| author_facet | Elena V. Chernikova Yaroslav V. Kudryavtsev |
| author_sort | Elena V. Chernikova |
| collection | DOAJ |
| description | The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functional polymers and their controlled conjugation with biomolecules, drugs, and inorganic surfaces. In this review, we discuss the results obtained with reversible addition–fragmentation chain transfer (RAFT) polymerization and different types of click reactions on low- and high-molar-mass reactants. Our classification of literature sources is based on the typical structure of macromolecules produced by the RAFT technique. The review addresses click reactions, immediate or preceded by a modification of another type, on the leaving and stabilizing groups inherited by a growing macromolecule from the chain transfer agent, as well as on the side groups coming from monomers entering the polymerization process. Architecture and self-assembling properties of the resulting polymers are briefly discussed with regard to their potential functional applications, which include drug delivery, protein recognition, anti-fouling and anti-corrosion coatings, the compatibilization of polymer blends, the modification of fillers to increase their dispersibility in polymer matrices, etc. |
| first_indexed | 2024-03-09T23:15:37Z |
| format | Article |
| id | doaj.art-71c16fb368ac4656b95810d2cce409b2 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T23:15:37Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-71c16fb368ac4656b95810d2cce409b22023-11-23T17:36:04ZengMDPI AGPolymers2073-43602022-01-0114357010.3390/polym14030570RAFT-Based Polymers for Click ReactionsElena V. Chernikova0Yaroslav V. Kudryavtsev1A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, 119991 Moscow, RussiaA.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, 119991 Moscow, RussiaThe parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functional polymers and their controlled conjugation with biomolecules, drugs, and inorganic surfaces. In this review, we discuss the results obtained with reversible addition–fragmentation chain transfer (RAFT) polymerization and different types of click reactions on low- and high-molar-mass reactants. Our classification of literature sources is based on the typical structure of macromolecules produced by the RAFT technique. The review addresses click reactions, immediate or preceded by a modification of another type, on the leaving and stabilizing groups inherited by a growing macromolecule from the chain transfer agent, as well as on the side groups coming from monomers entering the polymerization process. Architecture and self-assembling properties of the resulting polymers are briefly discussed with regard to their potential functional applications, which include drug delivery, protein recognition, anti-fouling and anti-corrosion coatings, the compatibilization of polymer blends, the modification of fillers to increase their dispersibility in polymer matrices, etc.https://www.mdpi.com/2073-4360/14/3/570click chemistryazide–alkyne cycloadditionthiol–ene and thiol–yne radical additionDiels–Alder cycloadditionRAFT polymerizationfunctional polymers |
| spellingShingle | Elena V. Chernikova Yaroslav V. Kudryavtsev RAFT-Based Polymers for Click Reactions Polymers click chemistry azide–alkyne cycloaddition thiol–ene and thiol–yne radical addition Diels–Alder cycloaddition RAFT polymerization functional polymers |
| title | RAFT-Based Polymers for Click Reactions |
| title_full | RAFT-Based Polymers for Click Reactions |
| title_fullStr | RAFT-Based Polymers for Click Reactions |
| title_full_unstemmed | RAFT-Based Polymers for Click Reactions |
| title_short | RAFT-Based Polymers for Click Reactions |
| title_sort | raft based polymers for click reactions |
| topic | click chemistry azide–alkyne cycloaddition thiol–ene and thiol–yne radical addition Diels–Alder cycloaddition RAFT polymerization functional polymers |
| url | https://www.mdpi.com/2073-4360/14/3/570 |
| work_keys_str_mv | AT elenavchernikova raftbasedpolymersforclickreactions AT yaroslavvkudryavtsev raftbasedpolymersforclickreactions |