Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

The advent of targeted therapies has led to tremendous improvements in treatment options and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by developing on-target or off-target resistance mechanisms. Gaining the ability to resist treatment is the rule rather tha...

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Bibliographic Details
Main Authors:	Paulina J. Dziubańska-Kusibab, Ekaterina Nevedomskaya, Bernard Haendler
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	International Journal of Molecular Sciences
Subjects:	cancer treatment resistance deep mutational scanning CRISPRko CRISPRi CRISPRa CRISPR base editing
Online Access:	https://www.mdpi.com/1422-0067/25/2/705

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