Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis
Abstract Background The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic prophylaxis and rising antimicrobial resistance rates. The objective of...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13643-020-01353-2 |
| _version_ | 1818882799168389120 |
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| author | Kathrin Bausch Soheila Aghlmandi Sarah Ursula Sutter Linda Maria Stamm Hannah Ewald Christian Appenzeller-Herzog Jan Adam Roth Andreas F. Widmer Hans-Helge Seifert |
| author_facet | Kathrin Bausch Soheila Aghlmandi Sarah Ursula Sutter Linda Maria Stamm Hannah Ewald Christian Appenzeller-Herzog Jan Adam Roth Andreas F. Widmer Hans-Helge Seifert |
| author_sort | Kathrin Bausch |
| collection | DOAJ |
| description | Abstract Background The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic prophylaxis and rising antimicrobial resistance rates. The objective of this systematic review and meta-analysis is to compare the impact of different antimicrobial prophylaxis schemes versus placebo on the prevention of postoperative UTI and asymptomatic bacteriuria. Methods We designed and registered a study protocol for a systematic review and meta-analysis of randomized controlled trials and non-randomized (e.g. cohort, case-control) studies examining any form of antibiotic prophylaxis in patients with transurethral resection of bladder tumours. Literature searches will be conducted in several electronic databases (from inception onwards), including MEDLINE (Ovid), EMBASE (Ovid), and the Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching conference abstracts. The primary outcome will be postoperative urinary tract infections. The secondary outcome will be asymptomatic bacteriuria. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using appropriate tools (e.g. Risk of Bias 2.0 tool and Newcastle-Ottawa Scale). If feasible, we will conduct random-effects meta-analysis of outcome data. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. study design, publication year, the setting of the study, and antibiotics regimen). We will also search, identify, and discuss potential risk factors for urinary tract infections following transurethral resection of bladder tumours. This may serve as basis for a scoping review. Discussion In times of rising antimicrobial resistance rates, sound evidence on the necessity of antibiotic prophylaxis is essential for implementation into guideline recommendations and for decision-making in clinical practice. Systematic review registration PROSPERO, CRD42019131733 |
| first_indexed | 2024-12-19T15:23:30Z |
| format | Article |
| id | doaj.art-71c3c76a5de3420fbc521c32bec95b15 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-19T15:23:30Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-71c3c76a5de3420fbc521c32bec95b152022-12-21T20:15:56ZengBMCSystematic Reviews2046-40532020-04-01911610.1186/s13643-020-01353-2Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysisKathrin Bausch0Soheila Aghlmandi1Sarah Ursula Sutter2Linda Maria Stamm3Hannah Ewald4Christian Appenzeller-Herzog5Jan Adam Roth6Andreas F. Widmer7Hans-Helge Seifert8Department of Urology, University Hospital BaselUniversity of BaselDepartment of Urology, University Hospital BaselDepartment of Urology, University Hospital BaselUniversity Medical Library, University of BaselUniversity Medical Library, University of BaselUniversity of BaselUniversity of BaselDepartment of Urology, University Hospital BaselAbstract Background The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic prophylaxis and rising antimicrobial resistance rates. The objective of this systematic review and meta-analysis is to compare the impact of different antimicrobial prophylaxis schemes versus placebo on the prevention of postoperative UTI and asymptomatic bacteriuria. Methods We designed and registered a study protocol for a systematic review and meta-analysis of randomized controlled trials and non-randomized (e.g. cohort, case-control) studies examining any form of antibiotic prophylaxis in patients with transurethral resection of bladder tumours. Literature searches will be conducted in several electronic databases (from inception onwards), including MEDLINE (Ovid), EMBASE (Ovid), and the Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching conference abstracts. The primary outcome will be postoperative urinary tract infections. The secondary outcome will be asymptomatic bacteriuria. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using appropriate tools (e.g. Risk of Bias 2.0 tool and Newcastle-Ottawa Scale). If feasible, we will conduct random-effects meta-analysis of outcome data. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. study design, publication year, the setting of the study, and antibiotics regimen). We will also search, identify, and discuss potential risk factors for urinary tract infections following transurethral resection of bladder tumours. This may serve as basis for a scoping review. Discussion In times of rising antimicrobial resistance rates, sound evidence on the necessity of antibiotic prophylaxis is essential for implementation into guideline recommendations and for decision-making in clinical practice. Systematic review registration PROSPERO, CRD42019131733http://link.springer.com/article/10.1186/s13643-020-01353-2AntibioticsAntibiotic prophylaxisAntibiotic resistanceAntimicrobial stewardshipBacteriuriaEndourological surgery |
| spellingShingle | Kathrin Bausch Soheila Aghlmandi Sarah Ursula Sutter Linda Maria Stamm Hannah Ewald Christian Appenzeller-Herzog Jan Adam Roth Andreas F. Widmer Hans-Helge Seifert Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis Systematic Reviews Antibiotics Antibiotic prophylaxis Antibiotic resistance Antimicrobial stewardship Bacteriuria Endourological surgery |
| title | Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis |
| title_full | Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis |
| title_fullStr | Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis |
| title_short | Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis |
| title_sort | antibiotic prophylaxis in transurethral resection of bladder tumours study protocol for a systematic review and meta analysis |
| topic | Antibiotics Antibiotic prophylaxis Antibiotic resistance Antimicrobial stewardship Bacteriuria Endourological surgery |
| url | http://link.springer.com/article/10.1186/s13643-020-01353-2 |
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