The Role of Innate Immune Cells in Tumor Invasion and Metastasis
Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the micro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/23/5885 |
| _version_ | 1797507988661993472 |
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| author | Yu-Kuan Huang Rita A. Busuttil Alex Boussioutas |
| author_facet | Yu-Kuan Huang Rita A. Busuttil Alex Boussioutas |
| author_sort | Yu-Kuan Huang |
| collection | DOAJ |
| description | Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. In the era of immune therapies, it is critical to understand how different innate immune cell populations are involved in this process. This review summarizes recent literature describing the roles of innate immune cells during the tumor metastatic cascade. |
| first_indexed | 2024-03-10T04:56:13Z |
| format | Article |
| id | doaj.art-71c47e6a5c854cd8aeba02c52b6fff45 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:56:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-71c47e6a5c854cd8aeba02c52b6fff452023-11-23T02:10:52ZengMDPI AGCancers2072-66942021-11-011323588510.3390/cancers13235885The Role of Innate Immune Cells in Tumor Invasion and MetastasisYu-Kuan Huang0Rita A. Busuttil1Alex Boussioutas2Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, AustraliaMetastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. In the era of immune therapies, it is critical to understand how different innate immune cell populations are involved in this process. This review summarizes recent literature describing the roles of innate immune cells during the tumor metastatic cascade.https://www.mdpi.com/2072-6694/13/23/5885innate immunityinvasionmetastasiscancerinnate immunology |
| spellingShingle | Yu-Kuan Huang Rita A. Busuttil Alex Boussioutas The Role of Innate Immune Cells in Tumor Invasion and Metastasis Cancers innate immunity invasion metastasis cancer innate immunology |
| title | The Role of Innate Immune Cells in Tumor Invasion and Metastasis |
| title_full | The Role of Innate Immune Cells in Tumor Invasion and Metastasis |
| title_fullStr | The Role of Innate Immune Cells in Tumor Invasion and Metastasis |
| title_full_unstemmed | The Role of Innate Immune Cells in Tumor Invasion and Metastasis |
| title_short | The Role of Innate Immune Cells in Tumor Invasion and Metastasis |
| title_sort | role of innate immune cells in tumor invasion and metastasis |
| topic | innate immunity invasion metastasis cancer innate immunology |
| url | https://www.mdpi.com/2072-6694/13/23/5885 |
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