Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/21/15972 |
| _version_ | 1797631791563014144 |
|---|---|
| author | Somayeh Vafaei Michał Ciebiera Mervat M. Omran Mohammad Mousaei Ghasroldasht Qiwei Yang Tanya Leake Rochelle Wolfe Mohamed Ali Ayman Al-Hendy |
| author_facet | Somayeh Vafaei Michał Ciebiera Mervat M. Omran Mohammad Mousaei Ghasroldasht Qiwei Yang Tanya Leake Rochelle Wolfe Mohamed Ali Ayman Al-Hendy |
| author_sort | Somayeh Vafaei |
| collection | DOAJ |
| description | Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide. |
| first_indexed | 2024-03-11T11:27:21Z |
| format | Article |
| id | doaj.art-71c5a09cf4a4494991f389beb9abc986 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:27:21Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71c5a09cf4a4494991f389beb9abc9862023-11-10T15:05:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124211597210.3390/ijms242115972Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)Somayeh Vafaei0Michał Ciebiera1Mervat M. Omran2Mohammad Mousaei Ghasroldasht3Qiwei Yang4Tanya Leake5Rochelle Wolfe6Mohamed Ali7Ayman Al-Hendy8Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USASecond Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 00-189 Warsaw, PolandDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USADepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USADepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USAThe White Dress Project, Atlanta, GA 30309, USAThe White Dress Project, Atlanta, GA 30309, USADepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USADepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USAUterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide.https://www.mdpi.com/1422-0067/24/21/15972uterine fibroidleiomyomasecondary preventionvitamin D3EGCGreproductive health |
| spellingShingle | Somayeh Vafaei Michał Ciebiera Mervat M. Omran Mohammad Mousaei Ghasroldasht Qiwei Yang Tanya Leake Rochelle Wolfe Mohamed Ali Ayman Al-Hendy Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) International Journal of Molecular Sciences uterine fibroid leiomyoma secondary prevention vitamin D3 EGCG reproductive health |
| title | Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) |
| title_full | Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) |
| title_fullStr | Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) |
| title_full_unstemmed | Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) |
| title_short | Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach) |
| title_sort | evidence based approach for secondary prevention of uterine fibroids the escape approach |
| topic | uterine fibroid leiomyoma secondary prevention vitamin D3 EGCG reproductive health |
| url | https://www.mdpi.com/1422-0067/24/21/15972 |
| work_keys_str_mv | AT somayehvafaei evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT michałciebiera evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT mervatmomran evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT mohammadmousaeighasroldasht evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT qiweiyang evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT tanyaleake evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT rochellewolfe evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT mohamedali evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach AT aymanalhendy evidencebasedapproachforsecondarypreventionofuterinefibroidstheescapeapproach |