Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice

Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice

All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, Fasudil and Lonafarnib, targeting synaptic formation (i.e., Wnt signaling) and ce...

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Bibliographic Details
Main Authors: Christiana Bjorkli, Mary Hemler, Joshua B. Julian, Axel Sandvig, Ioanna Sandvig
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
microdialysis
repurposed drugs
Wnt signalling
mTor pathway
amyloid plaques
neurofibrillary tangles
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.913971/full

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