Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next?
The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNAs (lncRNAs) has gathered speed in recent y...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
|
| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/5/3/43 |
| _version_ | 1819141050374029312 |
|---|---|
| author | Katie A. West Dimitris Lagos |
| author_facet | Katie A. West Dimitris Lagos |
| author_sort | Katie A. West |
| collection | DOAJ |
| description | The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a growing body of evidence has implicated lncRNAs in a vast range of cellular functions including gene regulation, chromosome organisation and splicing. T helper cells offer an ideal platform for the study of lncRNAs given they function as part of a complex cellular network and undergo remarkable and finely regulated gene expression changes upon antigenic stimulation. Using various knock down and RNA interaction studies several lncRNAs have been shown to be crucial for T helper cell differentiation, activation and function. Given that RNA targeting therapeutics are rapidly gaining attention, further understanding the mechanistic role of lncRNAs in a T helper context is an exciting area of research, as it may unearth a wide range of new candidate targets for treatment of CD4<sup>+</sup> mediated pathologies. |
| first_indexed | 2024-12-22T11:48:17Z |
| format | Article |
| id | doaj.art-71c8a388525b40c29704143bc034b095 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-12-22T11:48:17Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-71c8a388525b40c29704143bc034b0952022-12-21T18:27:05ZengMDPI AGNon-Coding RNA2311-553X2019-07-01534310.3390/ncrna5030043ncrna5030043Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next?Katie A. West0Dimitris Lagos1York Biomedical Research Institute, University of York, Wentworth Way, York YO10 5DD, UKYork Biomedical Research Institute, University of York, Wentworth Way, York YO10 5DD, UKThe non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a growing body of evidence has implicated lncRNAs in a vast range of cellular functions including gene regulation, chromosome organisation and splicing. T helper cells offer an ideal platform for the study of lncRNAs given they function as part of a complex cellular network and undergo remarkable and finely regulated gene expression changes upon antigenic stimulation. Using various knock down and RNA interaction studies several lncRNAs have been shown to be crucial for T helper cell differentiation, activation and function. Given that RNA targeting therapeutics are rapidly gaining attention, further understanding the mechanistic role of lncRNAs in a T helper context is an exciting area of research, as it may unearth a wide range of new candidate targets for treatment of CD4<sup>+</sup> mediated pathologies.https://www.mdpi.com/2311-553X/5/3/43long non-coding RNAadaptive immunityTh cellsinflammationinfection |
| spellingShingle | Katie A. West Dimitris Lagos Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? Non-Coding RNA long non-coding RNA adaptive immunity Th cells inflammation infection |
| title | Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? |
| title_full | Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? |
| title_fullStr | Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? |
| title_full_unstemmed | Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? |
| title_short | Long Non-Coding RNA Function in CD4<sup>+</sup> T Cells: What We Know and What Next? |
| title_sort | long non coding rna function in cd4 sup sup t cells what we know and what next |
| topic | long non-coding RNA adaptive immunity Th cells inflammation infection |
| url | https://www.mdpi.com/2311-553X/5/3/43 |
| work_keys_str_mv | AT katieawest longnoncodingrnafunctionincd4supsuptcellswhatweknowandwhatnext AT dimitrislagos longnoncodingrnafunctionincd4supsuptcellswhatweknowandwhatnext |