Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression
Health-related quality of life was examined in 49 patients with hepatitis C virus with no psychiatric history who received interferon (IFN)-α treatment. Quality of life was assessed at baseline, at 3-time points during IFN-α therapy and at 1-6 month follow-up, using SF-36. Hepatitis C virus patients...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-03-01
|
| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/5632 |
| _version_ | 1797935031463706624 |
|---|---|
| author | Ciro Conversano Claudia Carmassi Marina Carlini Giulia Casu Paola Gremigni Liliana Dell’Osso |
| author_facet | Ciro Conversano Claudia Carmassi Marina Carlini Giulia Casu Paola Gremigni Liliana Dell’Osso |
| author_sort | Ciro Conversano |
| collection | DOAJ |
| description | Health-related quality of life was examined in 49 patients with hepatitis C virus with no psychiatric history who received interferon (IFN)-α treatment. Quality of life was assessed at baseline, at 3-time points during IFN-α therapy and at 1-6 month follow-up, using SF-36. Hepatitis C virus patients showed poorer physical functioning and better social and mental functioning than a normal population. Significant decreases from baseline SF-36 scores were observed at an early phase of treatment. Six patients developed major depression during IFN-α treatment. At baseline, they had reported more bodily pain than patients who did not develop depression during treatment. Planned contrasts revealed that worsening in some dimensions of quality of life at 2 months was greater in depressed than in non-depressed patients. Results suggest that depressive symptoms should be accurately monitored during IFN-α therapy even in patients with no psychiatric history, especially if they present with bodily pain. |
| first_indexed | 2024-04-10T18:08:13Z |
| format | Article |
| id | doaj.art-71c90dec79ca4ef9b85c1a9aff0fca23 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:08:13Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-71c90dec79ca4ef9b85c1a9aff0fca232023-02-02T11:49:12ZengMDPI AGHematology Reports2038-83222038-83302015-03-017110.4081/hr.2015.56323016Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depressionCiro Conversano0Claudia Carmassi1Marina Carlini2Giulia Casu3Paola Gremigni4Liliana Dell’Osso5Section of Psychiatry, Department of Clinical and Experimental Medicine, University of PisaSection of Psychiatry, Department of Clinical and Experimental Medicine, University of PisaSection of Psychiatry, Department of Clinical and Experimental Medicine, University of PisaDepartment of Psychology, University of BolognaSection of Psychiatry, Department of Clinical and Experimental Medicine, University of PisaSection of Psychiatry, Department of Clinical and Experimental Medicine, University of PisaHealth-related quality of life was examined in 49 patients with hepatitis C virus with no psychiatric history who received interferon (IFN)-α treatment. Quality of life was assessed at baseline, at 3-time points during IFN-α therapy and at 1-6 month follow-up, using SF-36. Hepatitis C virus patients showed poorer physical functioning and better social and mental functioning than a normal population. Significant decreases from baseline SF-36 scores were observed at an early phase of treatment. Six patients developed major depression during IFN-α treatment. At baseline, they had reported more bodily pain than patients who did not develop depression during treatment. Planned contrasts revealed that worsening in some dimensions of quality of life at 2 months was greater in depressed than in non-depressed patients. Results suggest that depressive symptoms should be accurately monitored during IFN-α therapy even in patients with no psychiatric history, especially if they present with bodily pain.http://www.pagepress.org/journals/index.php/hr/article/view/5632depression, HCV, interferon, quality of life |
| spellingShingle | Ciro Conversano Claudia Carmassi Marina Carlini Giulia Casu Paola Gremigni Liliana Dell’Osso Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression Hematology Reports depression, HCV, interferon, quality of life |
| title | Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression |
| title_full | Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression |
| title_fullStr | Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression |
| title_full_unstemmed | Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression |
| title_short | Interferon α therapy in patients with chronic hepatitis C infection: quality of life and depression |
| title_sort | interferon α therapy in patients with chronic hepatitis c infection quality of life and depression |
| topic | depression, HCV, interferon, quality of life |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/5632 |
| work_keys_str_mv | AT ciroconversano interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression AT claudiacarmassi interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression AT marinacarlini interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression AT giuliacasu interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression AT paolagremigni interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression AT lilianadellosso interferonatherapyinpatientswithchronichepatitiscinfectionqualityoflifeanddepression |