Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020
(1) Background: This paper aims to assess temporal trends (2016–2020) in incidence, patient’s characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/11/1534 |
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| author | Belén López-Muñiz Ballesteros Ana Lopez-de-Andres Rodrigo Jimenez-Garcia Jose J. Zamorano-Leon David Carabantes-Alarcon Natividad Cuadrado-Corrales Jose L. Del-Barrio Napoleon Perez-Farinos Javier De Miguel-Díez |
| author_facet | Belén López-Muñiz Ballesteros Ana Lopez-de-Andres Rodrigo Jimenez-Garcia Jose J. Zamorano-Leon David Carabantes-Alarcon Natividad Cuadrado-Corrales Jose L. Del-Barrio Napoleon Perez-Farinos Javier De Miguel-Díez |
| author_sort | Belén López-Muñiz Ballesteros |
| collection | DOAJ |
| description | (1) Background: This paper aims to assess temporal trends (2016–2020) in incidence, patient’s characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We also analyse the effect of the COVID-19 pandemic on LTx in these populations. (2) Methods: A retrospective, population-based observational study was conducted using the Spanish National Hospital Discharge Database. Multivariable adjustment was conducted with logistic regression to analyse the IHM. (3) Results: We identified 1777 admissions for LTx during the study period, of which 573 (32.2%) were performed in patients with IPF. The number of hospital admissions for LTx rose from 2016 to 2020, both in patients with and without IPF, but a marked reduction was observed from year 2019 to year 2020. Over time, the proportion of single LTx decreased and bilateral LTx increased significantly in both groups. The incidence of LTx complications increased significantly over time along with the increase in the incidence of IPF. No significant differences in the incidence of complications or in the IHM between patients with and without IPF were found. Suffering any complication of the LTx and pulmonary hypertension were conditions positively associated with IHM in patients with and without IPF. The IHM remained stable from 2016 to 2020 in both study populations and was not affected by the COVID pandemic. (4) Conclusions: Patients with IPF account for almost a third of all lung transplants. The number of LTx increased over time in patients with and without IPF, but a marked reduction was observed from 2019 to 2020. Although the proportion of LTx complications increased significantly over time in both groups, the IHM did not change. IPF was not associated with increased complications or IHM after LTx. |
| first_indexed | 2024-03-11T03:06:38Z |
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| id | doaj.art-71c9757852354e8a9d58bb84feb25ae1 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T03:06:38Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-71c9757852354e8a9d58bb84feb25ae12023-11-18T07:52:49ZengMDPI AGHealthcare2227-90322023-05-011111153410.3390/healthcare11111534Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020Belén López-Muñiz Ballesteros0Ana Lopez-de-Andres1Rodrigo Jimenez-Garcia2Jose J. Zamorano-Leon3David Carabantes-Alarcon4Natividad Cuadrado-Corrales5Jose L. Del-Barrio6Napoleon Perez-Farinos7Javier De Miguel-Díez8Respiratory Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Public Health and Maternal & Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health and Maternal & Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health and Maternal & Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health and Maternal & Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health and Maternal & Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainPreventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, 28933 Alcorcón, SpainEpi-PHAAN Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA), School of Medicine, Universidad de Málaga, 29071 Málaga, SpainRespiratory Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain(1) Background: This paper aims to assess temporal trends (2016–2020) in incidence, patient’s characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We also analyse the effect of the COVID-19 pandemic on LTx in these populations. (2) Methods: A retrospective, population-based observational study was conducted using the Spanish National Hospital Discharge Database. Multivariable adjustment was conducted with logistic regression to analyse the IHM. (3) Results: We identified 1777 admissions for LTx during the study period, of which 573 (32.2%) were performed in patients with IPF. The number of hospital admissions for LTx rose from 2016 to 2020, both in patients with and without IPF, but a marked reduction was observed from year 2019 to year 2020. Over time, the proportion of single LTx decreased and bilateral LTx increased significantly in both groups. The incidence of LTx complications increased significantly over time along with the increase in the incidence of IPF. No significant differences in the incidence of complications or in the IHM between patients with and without IPF were found. Suffering any complication of the LTx and pulmonary hypertension were conditions positively associated with IHM in patients with and without IPF. The IHM remained stable from 2016 to 2020 in both study populations and was not affected by the COVID pandemic. (4) Conclusions: Patients with IPF account for almost a third of all lung transplants. The number of LTx increased over time in patients with and without IPF, but a marked reduction was observed from 2019 to 2020. Although the proportion of LTx complications increased significantly over time in both groups, the IHM did not change. IPF was not associated with increased complications or IHM after LTx.https://www.mdpi.com/2227-9032/11/11/1534lung transplantidiopathic pulmonary fibrosisincidencecomplicationsin-hospital mortalityCOVID-19 pandemic |
| spellingShingle | Belén López-Muñiz Ballesteros Ana Lopez-de-Andres Rodrigo Jimenez-Garcia Jose J. Zamorano-Leon David Carabantes-Alarcon Natividad Cuadrado-Corrales Jose L. Del-Barrio Napoleon Perez-Farinos Javier De Miguel-Díez Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 Healthcare lung transplant idiopathic pulmonary fibrosis incidence complications in-hospital mortality COVID-19 pandemic |
| title | Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 |
| title_full | Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 |
| title_fullStr | Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 |
| title_full_unstemmed | Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 |
| title_short | Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020 |
| title_sort | trends and outcomes in lung transplantation in patients with and without idiopathic pulmonary fibrosis in spain during the period 2016 2020 |
| topic | lung transplant idiopathic pulmonary fibrosis incidence complications in-hospital mortality COVID-19 pandemic |
| url | https://www.mdpi.com/2227-9032/11/11/1534 |
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