Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model
Asthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among innat...
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MDPI AG
2020-05-01
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author | Yuichiro Yasuda Tatsuya Nagano Kazuyuki Kobayashi Yoshihiro Nishimura |
author_facet | Yuichiro Yasuda Tatsuya Nagano Kazuyuki Kobayashi Yoshihiro Nishimura |
author_sort | Yuichiro Yasuda |
collection | DOAJ |
description | Asthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among innate immune cells, group 2 innate lymphoid cells (ILC2s) have been considered to be crucial for eosinophilic airway inflammation by releasing T helper 2 cytokines. Moreover, house dust mites (HDMs) belonging to group 1 act on airway epithelial cells not only as allergens but also as cysteine proteases. The production of interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP) from airway epithelial cells was induced by the protease activity of HDMs. These cytokines activate ILC2s, and activated ILC2s produce IL-5, IL-9, IL-13, and amphiregulin. Hence, the HDM-induced asthma mouse model greatly contributes to understanding asthma pathogenesis. In this review, we highlight the relationship between ILC2s and the HDM in the asthma mouse model to help researchers and clinicians not only choose a proper asthma mouse model but also to understand the molecular mechanisms underlying HDM-induced asthma. |
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format | Article |
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issn | 2073-4409 |
language | English |
last_indexed | 2024-03-10T19:56:27Z |
publishDate | 2020-05-01 |
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spelling | doaj.art-71c9f7ac181a4086b35465b554d3c8002023-11-19T23:53:46ZengMDPI AGCells2073-44092020-05-0195117810.3390/cells9051178Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse ModelYuichiro Yasuda0Tatsuya Nagano1Kazuyuki Kobayashi2Yoshihiro Nishimura3Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, Hyogo 650-0017, JapanDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, Hyogo 650-0017, JapanDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, Hyogo 650-0017, JapanDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, Hyogo 650-0017, JapanAsthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among innate immune cells, group 2 innate lymphoid cells (ILC2s) have been considered to be crucial for eosinophilic airway inflammation by releasing T helper 2 cytokines. Moreover, house dust mites (HDMs) belonging to group 1 act on airway epithelial cells not only as allergens but also as cysteine proteases. The production of interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP) from airway epithelial cells was induced by the protease activity of HDMs. These cytokines activate ILC2s, and activated ILC2s produce IL-5, IL-9, IL-13, and amphiregulin. Hence, the HDM-induced asthma mouse model greatly contributes to understanding asthma pathogenesis. In this review, we highlight the relationship between ILC2s and the HDM in the asthma mouse model to help researchers and clinicians not only choose a proper asthma mouse model but also to understand the molecular mechanisms underlying HDM-induced asthma.https://www.mdpi.com/2073-4409/9/5/1178asthmahouse dust miteinnate lymphoid cell 2mouse model |
spellingShingle | Yuichiro Yasuda Tatsuya Nagano Kazuyuki Kobayashi Yoshihiro Nishimura Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model Cells asthma house dust mite innate lymphoid cell 2 mouse model |
title | Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model |
title_full | Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model |
title_fullStr | Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model |
title_full_unstemmed | Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model |
title_short | Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model |
title_sort | group 2 innate lymphoid cells and the house dust mite induced asthma mouse model |
topic | asthma house dust mite innate lymphoid cell 2 mouse model |
url | https://www.mdpi.com/2073-4409/9/5/1178 |
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