Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia
IntroductionThe relationship between sensory impairments and the risk of dementia is inconclusive. We aim to investigate the association of visual impairment (VI), hearing impairment (HI), and dual sensory impairment (DSI) with incident dementia.MethodsThe UK Biobank study recruited more than 500,00...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.872967/full |
| _version_ | 1818211596021792768 |
|---|---|
| author | Wenyi Hu Wenyi Hu Wenyi Hu Yueye Wang Wei Wang Xinyu Zhang Xianwen Shang Huan Liao Yifan Chen Yu Huang Xueli Zhang Shulin Tang Honghua Yu Xiaohong Yang Mingguang He Mingguang He Mingguang He Mingguang He Zhuoting Zhu Zhuoting Zhu |
| author_facet | Wenyi Hu Wenyi Hu Wenyi Hu Yueye Wang Wei Wang Xinyu Zhang Xianwen Shang Huan Liao Yifan Chen Yu Huang Xueli Zhang Shulin Tang Honghua Yu Xiaohong Yang Mingguang He Mingguang He Mingguang He Mingguang He Zhuoting Zhu Zhuoting Zhu |
| author_sort | Wenyi Hu |
| collection | DOAJ |
| description | IntroductionThe relationship between sensory impairments and the risk of dementia is inconclusive. We aim to investigate the association of visual impairment (VI), hearing impairment (HI), and dual sensory impairment (DSI) with incident dementia.MethodsThe UK Biobank study recruited more than 500,000 participants aged 40–69 years across the United Kingdom. Participants with available visual acuity (VA) measurements and speech-reception-threshold (SRT) information and free of dementia at the baseline assessment were included in the analysis. VI was defined as VA worse than 0.3 LogMAR units and HI were defined as an SRT of −5.5 dB or over. DSI was defined as the presence of both VI and HI. Incident dementia was identified through linked data to primary care or hospital admission records and death registries. Multivariable Cox proportional hazard regression models were used to examine the association of VI, HI, and DSI with incident dementia.ResultsAmong 113,511 participants (mean age: 56.8 ± 8.09 years, female: 54.4%), a total number of 1,135 (1.00%) cases of incident dementia were identified during a median follow up period of 11.1 years [interquartile range (IQR): 10.9–11.4 years]. The incidence of dementia showed significant differences among the non-sensory impairment (NSI) group, VI-only group, HI-only group, and DSI group (p < 0.001). After adjusting for demographic, lifestyle, health, and genetic factors, isolated VI (HR = 1.50, 95% CI: 1.06–2.12, p = 0.023), isolated HI (HR = 1.42, 95% CI:1.20–1.69, p < 0.001), and DSI (HR = 1.82, 95% CI: 1.10–3.00, p = 0.020) were independently associated with higher risks of incident dementia.ConclusionsVisual, hearing, and dual sensory impairments were associated with an increased risk of developing dementia, suggesting that visual and hearing impairments are modifiable risk factors that can be targeted to prevent dementia. |
| first_indexed | 2024-12-12T05:35:00Z |
| format | Article |
| id | doaj.art-71cb2818dd6b42c3ac2aa7a4527c408d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T05:35:00Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-71cb2818dd6b42c3ac2aa7a4527c408d2022-12-22T00:36:10ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.872967872967Association of Visual, Hearing, and Dual Sensory Impairment With Incident DementiaWenyi Hu0Wenyi Hu1Wenyi Hu2Yueye Wang3Wei Wang4Xinyu Zhang5Xianwen Shang6Huan Liao7Yifan Chen8Yu Huang9Xueli Zhang10Shulin Tang11Honghua Yu12Xiaohong Yang13Mingguang He14Mingguang He15Mingguang He16Mingguang He17Zhuoting Zhu18Zhuoting Zhu19Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaCentre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, AustraliaOphthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, AustraliaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaShanghai Jiaotong University School of Medicine, Shanghai, ChinaCentre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, AustraliaNeural Regeneration Group, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, GermanyJohn Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United KingdomDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaCentre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, AustraliaOphthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, AustraliaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, ChinaCentre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, AustraliaIntroductionThe relationship between sensory impairments and the risk of dementia is inconclusive. We aim to investigate the association of visual impairment (VI), hearing impairment (HI), and dual sensory impairment (DSI) with incident dementia.MethodsThe UK Biobank study recruited more than 500,000 participants aged 40–69 years across the United Kingdom. Participants with available visual acuity (VA) measurements and speech-reception-threshold (SRT) information and free of dementia at the baseline assessment were included in the analysis. VI was defined as VA worse than 0.3 LogMAR units and HI were defined as an SRT of −5.5 dB or over. DSI was defined as the presence of both VI and HI. Incident dementia was identified through linked data to primary care or hospital admission records and death registries. Multivariable Cox proportional hazard regression models were used to examine the association of VI, HI, and DSI with incident dementia.ResultsAmong 113,511 participants (mean age: 56.8 ± 8.09 years, female: 54.4%), a total number of 1,135 (1.00%) cases of incident dementia were identified during a median follow up period of 11.1 years [interquartile range (IQR): 10.9–11.4 years]. The incidence of dementia showed significant differences among the non-sensory impairment (NSI) group, VI-only group, HI-only group, and DSI group (p < 0.001). After adjusting for demographic, lifestyle, health, and genetic factors, isolated VI (HR = 1.50, 95% CI: 1.06–2.12, p = 0.023), isolated HI (HR = 1.42, 95% CI:1.20–1.69, p < 0.001), and DSI (HR = 1.82, 95% CI: 1.10–3.00, p = 0.020) were independently associated with higher risks of incident dementia.ConclusionsVisual, hearing, and dual sensory impairments were associated with an increased risk of developing dementia, suggesting that visual and hearing impairments are modifiable risk factors that can be targeted to prevent dementia.https://www.frontiersin.org/articles/10.3389/fnagi.2022.872967/fulldual sensory impairment (DSI)dementiapreventionvisual impairment (VI)hearing impairment (HI) |
| spellingShingle | Wenyi Hu Wenyi Hu Wenyi Hu Yueye Wang Wei Wang Xinyu Zhang Xianwen Shang Huan Liao Yifan Chen Yu Huang Xueli Zhang Shulin Tang Honghua Yu Xiaohong Yang Mingguang He Mingguang He Mingguang He Mingguang He Zhuoting Zhu Zhuoting Zhu Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia Frontiers in Aging Neuroscience dual sensory impairment (DSI) dementia prevention visual impairment (VI) hearing impairment (HI) |
| title | Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia |
| title_full | Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia |
| title_fullStr | Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia |
| title_full_unstemmed | Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia |
| title_short | Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia |
| title_sort | association of visual hearing and dual sensory impairment with incident dementia |
| topic | dual sensory impairment (DSI) dementia prevention visual impairment (VI) hearing impairment (HI) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.872967/full |
| work_keys_str_mv | AT wenyihu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT wenyihu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT wenyihu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT yueyewang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT weiwang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT xinyuzhang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT xianwenshang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT huanliao associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT yifanchen associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT yuhuang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT xuelizhang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT shulintang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT honghuayu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT xiaohongyang associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT mingguanghe associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT mingguanghe associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT mingguanghe associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT mingguanghe associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT zhuotingzhu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia AT zhuotingzhu associationofvisualhearinganddualsensoryimpairmentwithincidentdementia |